Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells

Zinc finger DHHC-type palmitoyltransferase 13-mediated S-palmitoylation of GNA13 from Sertoli cell-derived extracellular vesicles inhibits autophagy in spermatogonial stem cells

Abstract Extracellular vesicles (EVs) originating from testicular somatic cells act as pivotal intermediaries in cell signaling crosstalk between spermatogenic cells and the testicular microenvironment. The intricate balance between palmitoylation and depalmitoylation governs the positioning of prot...

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Bibliographic Details
Main Authors: Heran Cao, Huihui Gao, Yan Li, Long Li, Shujuan Liu, Tianqi Jin, Yang Wang, Ye Gong, Shuiqiao Yuan, Wuzi Dong
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
GNA13
Palmitoylation
Sertoli cells
Extracellular vesicles
Autophagy
Spermatogonial stem cells
Online Access:https://doi.org/10.1186/s12964-025-02177-0
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