Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review
Adipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modu...
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| Format: | Article |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617157/full |
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| author | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_facet | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_sort | Mateusz Matwiejuk |
| collection | DOAJ |
| description | Adipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modulate immune responses, and release growth factors and cytokines underscores their potential in treating a wide range of immune-related skin conditions. ADMSCs significantly reduced various aspects of psoriasis, including scaling, thickness, and erythema. Moreover, cell-free therapy has even better therapeutic potential. It has been shown that ADMSC-derived exosomes can effectively alleviate pathological symptoms of atopic dermatitis, including clinical score, serum IgE levels, eosinophil amount, and infiltration of immune cells in skin lesions. This systematic review summarizes the most relevant preclinical and clinical studies on the therapeutic use of ADMSCs and their small extracellular vesicles in the treatment of common skin diseases like psoriasis, atopic dermatitis, localized scleroderma and acne vulgaris. |
| format | Article |
| id | doaj-art-c9a79a9c7ddd4517bf2dc30f7efcc5a2 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c9a79a9c7ddd4517bf2dc30f7efcc5a22025-08-22T05:26:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16171571617157Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic reviewMateusz Matwiejuk0Agnieszka Mikłosz1Hanna Myśliwiec2Adrian Chabowski3Iwona Flisiak4Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, Bialystok, PolandAdipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modulate immune responses, and release growth factors and cytokines underscores their potential in treating a wide range of immune-related skin conditions. ADMSCs significantly reduced various aspects of psoriasis, including scaling, thickness, and erythema. Moreover, cell-free therapy has even better therapeutic potential. It has been shown that ADMSC-derived exosomes can effectively alleviate pathological symptoms of atopic dermatitis, including clinical score, serum IgE levels, eosinophil amount, and infiltration of immune cells in skin lesions. This systematic review summarizes the most relevant preclinical and clinical studies on the therapeutic use of ADMSCs and their small extracellular vesicles in the treatment of common skin diseases like psoriasis, atopic dermatitis, localized scleroderma and acne vulgaris.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617157/fullADMSCssmall extracellular vesiclesexosomesskin diseasespsoriasisatopic dermatitis |
| spellingShingle | Mateusz Matwiejuk Agnieszka Mikłosz Hanna Myśliwiec Adrian Chabowski Iwona Flisiak Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review Frontiers in Immunology ADMSCs small extracellular vesicles exosomes skin diseases psoriasis atopic dermatitis |
| title | Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review |
| title_full | Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review |
| title_fullStr | Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review |
| title_full_unstemmed | Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review |
| title_short | Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review |
| title_sort | adipose derived mesenchymal stem cells and their derivatives in inflammatory skin diseases a systematic review |
| topic | ADMSCs small extracellular vesicles exosomes skin diseases psoriasis atopic dermatitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617157/full |
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