Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress
Irritable bowel syndrome (IBS) is a functional bowel disorder defined by recurrent abdominal pain, coupled with irregular bowel habits and alterations in the frequency as well as the consistency of stool. At present, IBS is considered as a disease of gut-brain interaction, and an increasing number o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996124003607 |
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| author | Jiaotao Xing Ying Li Jiali Hu Liyao Gu Guanghua Sun Xiangle Li |
| author_facet | Jiaotao Xing Ying Li Jiali Hu Liyao Gu Guanghua Sun Xiangle Li |
| author_sort | Jiaotao Xing |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is a functional bowel disorder defined by recurrent abdominal pain, coupled with irregular bowel habits and alterations in the frequency as well as the consistency of stool. At present, IBS is considered as a disease of gut-brain interaction, and an increasing number of studies are focusing on the brain-gut axis. However, the brain regions associated with IBS have not been fully studied yet. In this study, we utilized the chronic restraint stress (CRS) model to evoke IBS-like symptoms in mice, which were accompanied by anxiety-like behaviors and hyperalgesia. Through cFOS staining, we observed the activation of the lateral periaqueductal gray (LPAG) in the mice after CRS. By inhibiting the activity of the LPAG through tetanus toxin or chemogenetics, we found that IBS-like symptoms could be relieved, whereas chemogenetic activation of the LPAG induced IBS-like symptoms. Finally, we utilized the classic analgesic drug sufentanil and found that it could alleviate CRS-induced IBS-like symptoms. |
| format | Article |
| id | doaj-art-c9a6e4ede0c8440ab708f044af2887e4 |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-c9a6e4ede0c8440ab708f044af2887e42025-01-07T04:17:06ZengElsevierNeurobiology of Disease1095-953X2025-01-01204106758Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stressJiaotao Xing0Ying Li1Jiali Hu2Liyao Gu3Guanghua Sun4Xiangle Li5Department of Anorectal, Affiliated Nanhua Hospital, University of south China, Hengyang 421200, Hunan, ChinaDepartment of Anorectal, Affiliated Nanhua Hospital, University of south China, Hengyang 421200, Hunan, ChinaCentral Hospital of Hengyang City, Hengyang 421200, Hunan, ChinaCentral Hospital of Hengyang City, Hengyang 421200, Hunan, ChinaThe First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, Hengyang 421200, Hunan, ChinaCentral Hospital of Hengyang City, Hengyang 421200, Hunan, China; Corresponding author.Irritable bowel syndrome (IBS) is a functional bowel disorder defined by recurrent abdominal pain, coupled with irregular bowel habits and alterations in the frequency as well as the consistency of stool. At present, IBS is considered as a disease of gut-brain interaction, and an increasing number of studies are focusing on the brain-gut axis. However, the brain regions associated with IBS have not been fully studied yet. In this study, we utilized the chronic restraint stress (CRS) model to evoke IBS-like symptoms in mice, which were accompanied by anxiety-like behaviors and hyperalgesia. Through cFOS staining, we observed the activation of the lateral periaqueductal gray (LPAG) in the mice after CRS. By inhibiting the activity of the LPAG through tetanus toxin or chemogenetics, we found that IBS-like symptoms could be relieved, whereas chemogenetic activation of the LPAG induced IBS-like symptoms. Finally, we utilized the classic analgesic drug sufentanil and found that it could alleviate CRS-induced IBS-like symptoms.http://www.sciencedirect.com/science/article/pii/S0969996124003607Irritable bowel syndromeChronic restraint stressLateral periaqueductal graySufentanil |
| spellingShingle | Jiaotao Xing Ying Li Jiali Hu Liyao Gu Guanghua Sun Xiangle Li Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress Neurobiology of Disease Irritable bowel syndrome Chronic restraint stress Lateral periaqueductal gray Sufentanil |
| title | Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| title_full | Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| title_fullStr | Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| title_full_unstemmed | Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| title_short | Lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| title_sort | lateral periaqueductal gray participate in the regulation of irritable bowel syndrome induced by chronic restraint stress |
| topic | Irritable bowel syndrome Chronic restraint stress Lateral periaqueductal gray Sufentanil |
| url | http://www.sciencedirect.com/science/article/pii/S0969996124003607 |
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