Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study
A particular type of tumor that is frequently detected in female dogs who are sexually active is a mammary tumor. Neoplasia results from DNA-based alterations in cell cycle regulating genes. The mammary gland is prone to the formation of tumors due to its dynamic structure. The development of this t...
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-10-01
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| Series: | Jurnal Medik Veteriner |
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| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/44450 |
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| author | Palagan Senopati Sewoyo Anak Agung Ayu Mirah Adi Ida Bagus Oka Winaya I Wayan Wirata |
| author_facet | Palagan Senopati Sewoyo Anak Agung Ayu Mirah Adi Ida Bagus Oka Winaya I Wayan Wirata |
| author_sort | Palagan Senopati Sewoyo |
| collection | DOAJ |
| description | A particular type of tumor that is frequently detected in female dogs who are sexually active is a mammary tumor. Neoplasia results from DNA-based alterations in cell cycle regulating genes. The mammary gland is prone to the formation of tumors due to its dynamic structure. The development of this tumor is supported by numerous variables. It has been recently discovered that there is substantial evidence linking the BRCA2 gene to the process of cancer. Standard examination techniques, such as fine needle aspiration, histopathology, and immunohistochemistry, are used along with ancillary tests to determine the tumor type and degree of malignancy. The primary treatment option for malignant tumors is surgical resection followed by adjuvant chemotherapy; benign tumors necessitate surgical resection as well. Adjuvant therapy options include hormone therapy and non-steroidal anti-inflammatory medications. Tumor tissue undergoes angiogenesis as it grows and develops to accommodate the abundant supply of nutrients. Therefore, angiogenesis-inhibiting therapies can be utilized to halt the growth of tumor cells. A number of antiangiogenic medications are now being studied in clinical settings on humans, and several more are undergoing trials on animals. In addition to pharmaceuticals, viruses may be used as a therapeutic to block tumor angiogenesis. |
| format | Article |
| id | doaj-art-c9a3833d967746d482e70a4c30f51168 |
| institution | Kabale University |
| issn | 2615-7497 2581-012X |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj-art-c9a3833d967746d482e70a4c30f511682025-01-02T20:44:36ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-10-016227128710.20473/jmv.vol6.iss2.2023.271-28742532Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature StudyPalagan Senopati Sewoyo0https://orcid.org/0000-0002-8713-7725Anak Agung Ayu Mirah Adi1https://orcid.org/0000-0002-0983-252XIda Bagus Oka Winaya2https://orcid.org/0000-0003-3051-0901I Wayan Wirata3https://orcid.org/0009-0003-3281-499XMaster Program, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliDepartment of Pathobiology, Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliDepartment of Pathobiology, Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliDepartment of Clinical, Laboratory of Veterinary Surgery, Faculty of Veterinary Medicine, Udayana University, Denpasar, BaliA particular type of tumor that is frequently detected in female dogs who are sexually active is a mammary tumor. Neoplasia results from DNA-based alterations in cell cycle regulating genes. The mammary gland is prone to the formation of tumors due to its dynamic structure. The development of this tumor is supported by numerous variables. It has been recently discovered that there is substantial evidence linking the BRCA2 gene to the process of cancer. Standard examination techniques, such as fine needle aspiration, histopathology, and immunohistochemistry, are used along with ancillary tests to determine the tumor type and degree of malignancy. The primary treatment option for malignant tumors is surgical resection followed by adjuvant chemotherapy; benign tumors necessitate surgical resection as well. Adjuvant therapy options include hormone therapy and non-steroidal anti-inflammatory medications. Tumor tissue undergoes angiogenesis as it grows and develops to accommodate the abundant supply of nutrients. Therefore, angiogenesis-inhibiting therapies can be utilized to halt the growth of tumor cells. A number of antiangiogenic medications are now being studied in clinical settings on humans, and several more are undergoing trials on animals. In addition to pharmaceuticals, viruses may be used as a therapeutic to block tumor angiogenesis.https://e-journal.unair.ac.id/JMV/article/view/44450angiogenesisdogsmammary tumorstherapeutic targets |
| spellingShingle | Palagan Senopati Sewoyo Anak Agung Ayu Mirah Adi Ida Bagus Oka Winaya I Wayan Wirata Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study Jurnal Medik Veteriner angiogenesis dogs mammary tumors therapeutic targets |
| title | Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study |
| title_full | Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study |
| title_fullStr | Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study |
| title_full_unstemmed | Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study |
| title_short | Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study |
| title_sort | mammary tumors in dogs recent perspectives and antiangiogenesis as a therapeutic strategy literature study |
| topic | angiogenesis dogs mammary tumors therapeutic targets |
| url | https://e-journal.unair.ac.id/JMV/article/view/44450 |
| work_keys_str_mv | AT palagansenopatisewoyo mammarytumorsindogsrecentperspectivesandantiangiogenesisasatherapeuticstrategyliteraturestudy AT anakagungayumirahadi mammarytumorsindogsrecentperspectivesandantiangiogenesisasatherapeuticstrategyliteraturestudy AT idabagusokawinaya mammarytumorsindogsrecentperspectivesandantiangiogenesisasatherapeuticstrategyliteraturestudy AT iwayanwirata mammarytumorsindogsrecentperspectivesandantiangiogenesisasatherapeuticstrategyliteraturestudy |