Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt
Abstract Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 pol...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-13224-3 |
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| author | Roqaia E. Radwan Wafaa M. El-kholy Afaf Elsaed Ahmad Darwish |
| author_facet | Roqaia E. Radwan Wafaa M. El-kholy Afaf Elsaed Ahmad Darwish |
| author_sort | Roqaia E. Radwan |
| collection | DOAJ |
| description | Abstract Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls. Notably, specific variations in TNF-α (GA, AA genotypes, and dominant model) were associated with an increased risk of ALL, suggesting impaired apoptosis. Conversely, ALL patients exhibited significantly lower TGF-β levels, potentially promoting uncontrolled proliferation. Our findings suggest that lower TGF-β and the TNF-α (-308) dominant model are associated with an increased risk of ALL. Additionally, TGF-β demonstrated exceptional accuracy (AUC 0.995) as a potential marker, with 100% sensitivity and 96% specificity. These findings suggest that TNF-α and TGF-β may be associated with ALL susceptibility, though further research with larger and more diverse populations is necessary to confirm these results. |
| format | Article |
| id | doaj-art-c9a14cea39e04c1e91366b6ccce72bcf |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-c9a14cea39e04c1e91366b6ccce72bcf2024-12-15T12:09:32ZengBMCBMC Cancer1471-24072024-12-0124111310.1186/s12885-024-13224-3Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in EgyptRoqaia E. Radwan0Wafaa M. El-kholy1Afaf Elsaed2Ahmad Darwish3Physiology Section, Zoology Department, Faculty of Science, Mansoura UniversityPhysiology Section, Zoology Department, Faculty of Science, Mansoura UniversityGenetics Unit, Children Hospital, Mansoura UniversityHematology, Oncology and Bone Marrow Transplantation Unit, Pediatric Department, Faculty of Medicine, Mansoura UniversityAbstract Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls. Notably, specific variations in TNF-α (GA, AA genotypes, and dominant model) were associated with an increased risk of ALL, suggesting impaired apoptosis. Conversely, ALL patients exhibited significantly lower TGF-β levels, potentially promoting uncontrolled proliferation. Our findings suggest that lower TGF-β and the TNF-α (-308) dominant model are associated with an increased risk of ALL. Additionally, TGF-β demonstrated exceptional accuracy (AUC 0.995) as a potential marker, with 100% sensitivity and 96% specificity. These findings suggest that TNF-α and TGF-β may be associated with ALL susceptibility, though further research with larger and more diverse populations is necessary to confirm these results.https://doi.org/10.1186/s12885-024-13224-3ALLTNF-alphaTGF-betaSNPsCytokine levels |
| spellingShingle | Roqaia E. Radwan Wafaa M. El-kholy Afaf Elsaed Ahmad Darwish Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt BMC Cancer ALL TNF-alpha TGF-beta SNPs Cytokine levels |
| title | Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt |
| title_full | Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt |
| title_fullStr | Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt |
| title_full_unstemmed | Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt |
| title_short | Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt |
| title_sort | genetic predisposition meets cytokine imbalance the influence of tnf α 308 polymorphism and tgf β levels in pediatric acute lymphoblastic leukemia in egypt |
| topic | ALL TNF-alpha TGF-beta SNPs Cytokine levels |
| url | https://doi.org/10.1186/s12885-024-13224-3 |
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