Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording
Abstract This paper presents a thin-film, three-dimensional (3D) opto-electro array featuring four addressable microscale light-emitting diodes (LEDs) for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities. Inspired by the origami...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-05-01
|
| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-024-00842-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849311587167371264 |
|---|---|
| author | Yan Gong Xiang Liu Zebin Jiang Arthur Weber Wen Li |
| author_facet | Yan Gong Xiang Liu Zebin Jiang Arthur Weber Wen Li |
| author_sort | Yan Gong |
| collection | DOAJ |
| description | Abstract This paper presents a thin-film, three-dimensional (3D) opto-electro array featuring four addressable microscale light-emitting diodes (LEDs) for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities. Inspired by the origami concept, we have developed a meticulously designed “bridge+trench” structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal. Prior to device transformation, the shape and dimensions of the 2D array can be customized, enhancing its versatility for various applications. In addition, the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement. The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device. The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization. |
| format | Article |
| id | doaj-art-c99bfae2c55c4f0f9a03be96bb3e4a30 |
| institution | Kabale University |
| issn | 2055-7434 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj-art-c99bfae2c55c4f0f9a03be96bb3e4a302025-08-20T03:53:22ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342025-05-0111111410.1038/s41378-024-00842-xFoldable 3D opto-electro array for optogenetic neuromodulation and physiology recordingYan Gong0Xiang Liu1Zebin Jiang2Arthur Weber3Wen Li4Department of Electrical and Computer Engineering, Michigan State UniversityInstitute for Quantitative Health Science and Engineering, Michigan State UniversityDepartment of Electrical and Computer Engineering, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Electrical and Computer Engineering, Michigan State UniversityAbstract This paper presents a thin-film, three-dimensional (3D) opto-electro array featuring four addressable microscale light-emitting diodes (LEDs) for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities. Inspired by the origami concept, we have developed a meticulously designed “bridge+trench” structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal. Prior to device transformation, the shape and dimensions of the 2D array can be customized, enhancing its versatility for various applications. In addition, the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement. The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device. The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization.https://doi.org/10.1038/s41378-024-00842-x |
| spellingShingle | Yan Gong Xiang Liu Zebin Jiang Arthur Weber Wen Li Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording Microsystems & Nanoengineering |
| title | Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording |
| title_full | Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording |
| title_fullStr | Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording |
| title_full_unstemmed | Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording |
| title_short | Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording |
| title_sort | foldable 3d opto electro array for optogenetic neuromodulation and physiology recording |
| url | https://doi.org/10.1038/s41378-024-00842-x |
| work_keys_str_mv | AT yangong foldable3doptoelectroarrayforoptogeneticneuromodulationandphysiologyrecording AT xiangliu foldable3doptoelectroarrayforoptogeneticneuromodulationandphysiologyrecording AT zebinjiang foldable3doptoelectroarrayforoptogeneticneuromodulationandphysiologyrecording AT arthurweber foldable3doptoelectroarrayforoptogeneticneuromodulationandphysiologyrecording AT wenli foldable3doptoelectroarrayforoptogeneticneuromodulationandphysiologyrecording |