Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs
Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs)....
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004940 |
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| author | María Sancho-Albero Alessandra Decio Reha Akpinar Ada De Luigi Raffaella Giavazzi Luigi M. Terracciano Luisa De Cola |
| author_facet | María Sancho-Albero Alessandra Decio Reha Akpinar Ada De Luigi Raffaella Giavazzi Luigi M. Terracciano Luisa De Cola |
| author_sort | María Sancho-Albero |
| collection | DOAJ |
| description | Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis. Extracellular vesicles (EVs) have a similar ability in target only certain organs or to return to their original cells, showing home behavior. Here we report a strategy inspired by nature, using a combination of NPs and the targeting cell membranes of EVs. We implement the EV membranes, extracted by the EVs produced by melanoma B16-BL6 cells, as a coating of organosilica porous particles with the aim of targeting tumors and lung metastasis, while avoiding systemic effects and accumulation of the NPs in undesired organs. The tissue-specific fingerprint provided by the EVs-derived membranes from melanoma cells provides preferential uptake into the tumor and selective targeting of lungs. The ability of the EVs hybrid systems to behave as the natural EVs was demonstrated in vitro and in vivo in two different tumor models. As a proof of concept, the loading and release of doxorubicin, was investigated and its accumulation demonstrated in the expected tissues. |
| format | Article |
| id | doaj-art-c9861c2053d94dabb4308bfe1209ab49 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-c9861c2053d94dabb4308bfe1209ab492025-01-17T04:52:12ZengElsevierMaterials Today Bio2590-00642025-02-0130101433Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungsMaría Sancho-Albero0Alessandra Decio1Reha Akpinar2Ada De Luigi3Raffaella Giavazzi4Luigi M. Terracciano5Luisa De Cola6Department of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, Italy; Corresponding author.Department of Oncology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, ItalyIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, 20089, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, ItalyDepartment of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, ItalyDepartment of Oncology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, ItalyIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, 20089, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, ItalyDepartment of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, Italy; Department of Pharmaceutical Science, DISFARM. Università degli Studi di Milano, Milan, 20133, Italy; Corresponding author. Department of Biochemistry and Molecular Pharmacology. Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Via Mario Negri, 2, Milan, Italy.Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis. Extracellular vesicles (EVs) have a similar ability in target only certain organs or to return to their original cells, showing home behavior. Here we report a strategy inspired by nature, using a combination of NPs and the targeting cell membranes of EVs. We implement the EV membranes, extracted by the EVs produced by melanoma B16-BL6 cells, as a coating of organosilica porous particles with the aim of targeting tumors and lung metastasis, while avoiding systemic effects and accumulation of the NPs in undesired organs. The tissue-specific fingerprint provided by the EVs-derived membranes from melanoma cells provides preferential uptake into the tumor and selective targeting of lungs. The ability of the EVs hybrid systems to behave as the natural EVs was demonstrated in vitro and in vivo in two different tumor models. As a proof of concept, the loading and release of doxorubicin, was investigated and its accumulation demonstrated in the expected tissues.http://www.sciencedirect.com/science/article/pii/S2590006424004940 |
| spellingShingle | María Sancho-Albero Alessandra Decio Reha Akpinar Ada De Luigi Raffaella Giavazzi Luigi M. Terracciano Luisa De Cola Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs Materials Today Bio |
| title | Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| title_full | Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| title_fullStr | Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| title_full_unstemmed | Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| title_short | Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| title_sort | melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004940 |
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