Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications
The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lacto...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2021/8985179 |
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| author | Javad Sharifi-Rad Cristina Quispe Seyed Abdulmajid Ayatollahi Farzad Kobarfard Mariola Staniak Anna Stępień Katarzyna Czopek Surjit Sen Krishnendu Acharya Karl R. Matthews Bilge Sener Hari Prasad Devkota Celale Kırkın Beraat Özçelik Montserrat Victoriano Miquel Martorell Hafiz Ansar Rasul Suleria Mohammed M. Alshehri Deepak Chandran Manoj Kumar Natália Cruz-Martins William C. Cho |
| author_facet | Javad Sharifi-Rad Cristina Quispe Seyed Abdulmajid Ayatollahi Farzad Kobarfard Mariola Staniak Anna Stępień Katarzyna Czopek Surjit Sen Krishnendu Acharya Karl R. Matthews Bilge Sener Hari Prasad Devkota Celale Kırkın Beraat Özçelik Montserrat Victoriano Miquel Martorell Hafiz Ansar Rasul Suleria Mohammed M. Alshehri Deepak Chandran Manoj Kumar Natália Cruz-Martins William C. Cho |
| author_sort | Javad Sharifi-Rad |
| collection | DOAJ |
| description | The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed. |
| format | Article |
| id | doaj-art-c97c5f8cc3f14ef3adb50a624c327aef |
| institution | DOAJ |
| issn | 1745-4557 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-c97c5f8cc3f14ef3adb50a624c327aef2025-08-20T03:19:34ZengWileyJournal of Food Quality1745-45572021-01-01202110.1155/2021/8985179Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry ApplicationsJavad Sharifi-Rad0Cristina Quispe1Seyed Abdulmajid Ayatollahi2Farzad Kobarfard3Mariola Staniak4Anna Stępień5Katarzyna Czopek6Surjit Sen7Krishnendu Acharya8Karl R. Matthews9Bilge Sener10Hari Prasad Devkota11Celale Kırkın12Beraat Özçelik13Montserrat Victoriano14Miquel Martorell15Hafiz Ansar Rasul Suleria16Mohammed M. Alshehri17Deepak Chandran18Manoj Kumar19Natália Cruz-Martins20William C. Cho21Phytochemistry Research CenterFacultad de Ciencias de la SaludPhytochemistry Research CenterPhytochemistry Research CenterInstitute of Soil Science and Plant Cultivation–State Research InstituteInstitute of Soil Science and Plant Cultivation–State Research InstituteInstitute of Soil Science and Plant Cultivation–State Research InstituteMolecular and Applied Mycology and Plant Pathology LaboratoryMolecular and Applied Mycology and Plant Pathology LaboratoryDepartment of Food ScienceGazi UniversityGraduate School of Pharmaceutical SciencesDepartment Food EngineeringDepartment Food EngineeringDepartment of Nutrition and DieteticsDepartment of Nutrition and DieteticsDepartment of Agriculture and Food SystemsPharmaceutical Care DepartmentDepartment of Veterinary Sciences and Animal HusbandryChemical and Biochemical Processing DivisionFaculty of MedicineDepartment of Clinical OncologyThe Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.http://dx.doi.org/10.1155/2021/8985179 |
| spellingShingle | Javad Sharifi-Rad Cristina Quispe Seyed Abdulmajid Ayatollahi Farzad Kobarfard Mariola Staniak Anna Stępień Katarzyna Czopek Surjit Sen Krishnendu Acharya Karl R. Matthews Bilge Sener Hari Prasad Devkota Celale Kırkın Beraat Özçelik Montserrat Victoriano Miquel Martorell Hafiz Ansar Rasul Suleria Mohammed M. Alshehri Deepak Chandran Manoj Kumar Natália Cruz-Martins William C. Cho Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications Journal of Food Quality |
| title | Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications |
| title_full | Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications |
| title_fullStr | Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications |
| title_full_unstemmed | Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications |
| title_short | Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications |
| title_sort | chemical composition biological activity and health promoting effects of withania somnifera for pharma food industry applications |
| url | http://dx.doi.org/10.1155/2021/8985179 |
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