Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia
Objective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, th...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-04-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/461 |
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| author | I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva |
| author_facet | I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva |
| author_sort | I. E. Golub |
| collection | DOAJ |
| description | Objective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, the patients were divided into 5 groups: 1) EA with a local anesthetic; 2) EA in combination with a nonsteroidal anti-inflammatory drug (ketoprophen); 3) EA in combination with ketoprophen and subnarcotic doses of ketamine; 4) EA in combination with fentanyl and ketoprophen; 5) EA in combination with fentanyl, ketoprophen, and ketamine. Results. The developed procedure for prolonged multimodal EA allows the stabilization of hemodynamics, the concentration of cortisol and metabolites (glucose, lactate), and the values of regional blood flow. Conclusion. EA with a local anesthetic in combination with fentanyl, ketoprophen, and ketamine is the most effective method for analgesia in patients with CLEI in the preoperative period. Key words: multimodal analgesia. |
| format | Article |
| id | doaj-art-c977ba15f80c473b8d0219feb6030898 |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-c977ba15f80c473b8d0219feb60308982025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-04-016210.15360/1813-9779-2010-2-25461Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity IschemiaI. E. GolubA. Yu. NovikovL. V. SorokinaA. V. NeupokoevaObjective: to evaluate the efficiency of multimodal epidural analgesia (EA) in patients with chronic critical lower extremity ischemia (CLEI) in the preoperative period. Subjects and methods. A prospective randomized controlled study was conducted in 150 patients.According to the anesthesia mode, the patients were divided into 5 groups: 1) EA with a local anesthetic; 2) EA in combination with a nonsteroidal anti-inflammatory drug (ketoprophen); 3) EA in combination with ketoprophen and subnarcotic doses of ketamine; 4) EA in combination with fentanyl and ketoprophen; 5) EA in combination with fentanyl, ketoprophen, and ketamine. Results. The developed procedure for prolonged multimodal EA allows the stabilization of hemodynamics, the concentration of cortisol and metabolites (glucose, lactate), and the values of regional blood flow. Conclusion. EA with a local anesthetic in combination with fentanyl, ketoprophen, and ketamine is the most effective method for analgesia in patients with CLEI in the preoperative period. Key words: multimodal analgesia.https://www.reanimatology.com/rmt/article/view/461 |
| spellingShingle | I. E. Golub A. Yu. Novikov L. V. Sorokina A. V. Neupokoeva Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia Общая реаниматология |
| title | Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
| title_full | Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
| title_fullStr | Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
| title_full_unstemmed | Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
| title_short | Multimodality Therapy for Chronic Pain Syndrome in Critical Lower Extremity Ischemia |
| title_sort | multimodality therapy for chronic pain syndrome in critical lower extremity ischemia |
| url | https://www.reanimatology.com/rmt/article/view/461 |
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