Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression. However, the role of snoRNA in the epigenetics of tumors remains poorly understood due to the lack of sufficiently effective...

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Bibliographic Details
Main Authors: Minglu Zhang, Jianbo He, Rao Fu, Guojian Bao, Yijun Lu, Zechuan Zhang, Jiawu Yan, Jialu Ding, Fei Yang, Beicheng Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Genetics
Subjects:
2′-O-methylation
snoRNA
HCC
rRNA
RAS
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1620552/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1620552/full

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