Preclinical delayed toxicity studies of BCMA CAR T-cell injection in B-NDG mice with multiple myeloma

Preclinical delayed toxicity studies of BCMA CAR T-cell injection in B-NDG mice with multiple myeloma

PurposeBased on the efficacy data from the previous study of B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell injection, we further examined the delayed toxicity for 8 weeks after a single dose of BCMA CAR T-cell injection to observe possible toxic reactions.MethodsB-NDG mice...

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Bibliographic Details
Main Authors: Jianmin Guo, Qiqi Wu, Hongjian Li, Chun Liang, Jinlong Dai, Shuren Zhang, Cailing Dai, Jishuai Zhang, Yuying Wen, Wei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
chimeric antigen receptor T cells
immunotherapy
B-cell maturation antigen
cytokines
delayed toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1435934/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1435934/full

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