Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease

Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease

Abstract Congenital heart disease (CHD) is the most common birth defect in newborns, often requiring cardiac surgery with concomitant thymectomy that is known to increase disease susceptibility later in life. Studies of γδ T cells, which are one of the dominant T cells in the early fetal human thymu...

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Main Authors: Alexa Cramer, Tao Yang, Lennart Riemann, Vicente Almeida, Christoph Kammeyer, Yusuf E. Abu, Elisa Gluschke, Svea Kleiner, Ximena León-Lara, Anika Janssen, Alejandro Hofmann, Alexander Horke, Constantin von Kaisenberg, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51673-3
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