Revealing lactylation-mediated mechanisms and hub genes in heart failure pathogenesis

Revealing lactylation-mediated mechanisms and hub genes in heart failure pathogenesis

PurposeThis study explores lactylation's pivotal role in the disease progression of heart failure (HF).MethodsThe GSE57345 dataset, encompassing 177 HF samples and 136 normal controls (CTL), was sourced from Gene Expression Omnibus (GEO). Differentially expressed genes between HF and CTL groups...

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Bibliographic Details
Main Authors: Hongguang Xie, Yiqiang Wang, Xing Zhu, Lili Zhang, Heli Niu, Hongguang Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
lactylation
heart failure
macrophage polarization
JAK/STAT
bioinformatics analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1622958/full
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