EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma
Abstract Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy. Recent studies have discovered a pivotal role of the intratumoral microbiota in various cancers, yet it remains elusive in ACC. Here, we explored the intratumoral microbiome data derived from in silico identification, furth...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | iMeta |
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| Online Access: | https://doi.org/10.1002/imt2.102 |
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| author | Yuqing Li Dengwei Zhang Minghua Wang Haowen Jiang Chenchen Feng Yong‐Xin Li |
| author_facet | Yuqing Li Dengwei Zhang Minghua Wang Haowen Jiang Chenchen Feng Yong‐Xin Li |
| author_sort | Yuqing Li |
| collection | DOAJ |
| description | Abstract Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy. Recent studies have discovered a pivotal role of the intratumoral microbiota in various cancers, yet it remains elusive in ACC. Here, we explored the intratumoral microbiome data derived from in silico identification, further validated in an in‐house cohort by bacterial 16S rRNA fluorescence in situ hybridization and lipopolysaccharide staining. Unsupervised clustering determined two naturally distinct clusters of the intratumoral microbiome in ACC, which was associated with overall survival. The incorporation of microbial signatures enhanced the prognostic performance of the clinical stage in an immunity‐dependent manner. Genetic and transcriptomic association analyses identified significant upregulation of the cell cycle and p53 signaling pathways associated with microbial signatures for worsened prognosis. Our study not only supports the presence of intratumoral bacteria but also implies a prognostic and biological role of intratumoral microbiota in ACC, which can advance a better understanding of the biology of ACC. |
| format | Article |
| id | doaj-art-c91314afcfcc47cdb82ae06c954718e3 |
| institution | Kabale University |
| issn | 2770-596X |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj-art-c91314afcfcc47cdb82ae06c954718e32024-12-09T07:45:59ZengWileyiMeta2770-596X2023-05-0122n/an/a10.1002/imt2.102EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinomaYuqing Li0Dengwei Zhang1Minghua Wang2Haowen Jiang3Chenchen Feng4Yong‐Xin Li5Department of Urology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Chemistry and The Swire Institute of Marine Science The University of Hong Kong Hong Kong ChinaDepartment of Urology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Urology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Urology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Chemistry and The Swire Institute of Marine Science The University of Hong Kong Hong Kong ChinaAbstract Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy. Recent studies have discovered a pivotal role of the intratumoral microbiota in various cancers, yet it remains elusive in ACC. Here, we explored the intratumoral microbiome data derived from in silico identification, further validated in an in‐house cohort by bacterial 16S rRNA fluorescence in situ hybridization and lipopolysaccharide staining. Unsupervised clustering determined two naturally distinct clusters of the intratumoral microbiome in ACC, which was associated with overall survival. The incorporation of microbial signatures enhanced the prognostic performance of the clinical stage in an immunity‐dependent manner. Genetic and transcriptomic association analyses identified significant upregulation of the cell cycle and p53 signaling pathways associated with microbial signatures for worsened prognosis. Our study not only supports the presence of intratumoral bacteria but also implies a prognostic and biological role of intratumoral microbiota in ACC, which can advance a better understanding of the biology of ACC.https://doi.org/10.1002/imt2.102adrenocortical carcinomaintratumoral microbiotamicrobiomeprognosis |
| spellingShingle | Yuqing Li Dengwei Zhang Minghua Wang Haowen Jiang Chenchen Feng Yong‐Xin Li EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma iMeta adrenocortical carcinoma intratumoral microbiota microbiome prognosis |
| title | EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| title_full | EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| title_fullStr | EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| title_full_unstemmed | EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| title_short | EXPRESSION OF CONCERN: Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| title_sort | expression of concern intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma |
| topic | adrenocortical carcinoma intratumoral microbiota microbiome prognosis |
| url | https://doi.org/10.1002/imt2.102 |
| work_keys_str_mv | AT yuqingli expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma AT dengweizhang expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma AT minghuawang expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma AT haowenjiang expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma AT chenchenfeng expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma AT yongxinli expressionofconcernintratumoralmicrobiotaisassociatedwithprognosisinpatientswithadrenocorticalcarcinoma |