A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells

A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells

Abstract Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to improve cancer treatment. Here, we carried...

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Main Authors: Abir Arfaoui, Claire Rioualen, Violette Azzoni, Guillaume Pinna, Pascal Finetti, Julien Wicinski, Emmanuelle Josselin, Manon Macario, Rémy Castellano, Candi Léonard‐Stumpf, Anthony Bal, Abigaelle Gros, Sylvain Lossy, Maher Kharrat, Yves Collette, Francois Bertucci, Daniel Birnbaum, Hayet Douik, Ghislain Bidaut, Emmanuelle Charafe‐Jauffret, Christophe Ginestier
Format: Article
Language:English
Published: Springer Nature 2019-09-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
cancer stem cells
JQ1
RNAi screen
salinomycin
Online Access:https://doi.org/10.15252/emmm.201809930
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