Identification of altered immune cell types and molecular mechanisms in Alzheimer’s disease progression by single-cell RNA sequencing

Identification of altered immune cell types and molecular mechanisms in Alzheimer’s disease progression by single-cell RNA sequencing

IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of cognitive function. Understanding the molecular mechanisms is crucial for developing effective therapies.MethodsData from single-cell RNA sequencing (scRNA-seq) in the GSE181279 dataset...

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Bibliographic Details
Main Authors: Hua Lin, Li Su, Daniel Mao, Grace Yang, Qi Huang, Yating Lan, Jingyi Zeng, Wenyi Song, Guining Liang, Qingyan Wei, Donghua Zou, Rongjie Li, Chanhua Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
immune cells
single-cell RNA sequencing
UFC1
monocytes
tlymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1477327/full
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