Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?
The major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular me...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002977 |
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| author | José María Salazar Campos Lena F Burbulla Sarah Jäkel |
| author_facet | José María Salazar Campos Lena F Burbulla Sarah Jäkel |
| author_sort | José María Salazar Campos |
| collection | DOAJ |
| description | The major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's. Although these findings are of high relevance, particularly to the search for effective disease-modifying therapies, the actual functional role of oligodendrocytes in Parkinson's disease remains highly speculative and requires a concerted scientific effort to be better understood. This Unsolved Mystery discusses the limited understanding of oligodendrocytes in PD, highlighting unresolved questions regarding functional changes in oligodendroglia, the role of myelin in nigral dopaminergic neurons, the impact of the toxic environment, and the aggregation of alpha-synuclein within oligodendrocytes. |
| format | Article |
| id | doaj-art-c8de806684db47bd8f1c985c1b5f4586 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-c8de806684db47bd8f1c985c1b5f45862025-01-17T05:30:43ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-01-01231e300297710.1371/journal.pbio.3002977Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?José María Salazar CamposLena F BurbullaSarah JäkelThe major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's. Although these findings are of high relevance, particularly to the search for effective disease-modifying therapies, the actual functional role of oligodendrocytes in Parkinson's disease remains highly speculative and requires a concerted scientific effort to be better understood. This Unsolved Mystery discusses the limited understanding of oligodendrocytes in PD, highlighting unresolved questions regarding functional changes in oligodendroglia, the role of myelin in nigral dopaminergic neurons, the impact of the toxic environment, and the aggregation of alpha-synuclein within oligodendrocytes.https://doi.org/10.1371/journal.pbio.3002977 |
| spellingShingle | José María Salazar Campos Lena F Burbulla Sarah Jäkel Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? PLoS Biology |
| title | Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? |
| title_full | Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? |
| title_fullStr | Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? |
| title_full_unstemmed | Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? |
| title_short | Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? |
| title_sort | are oligodendrocytes bystanders or drivers of parkinson s disease pathology |
| url | https://doi.org/10.1371/journal.pbio.3002977 |
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