Time-trend costs of infection-related cancers in Japan: a systematic review
Abstract Introduction Although infection-related cancers are largely preventable through vaccination and screening, the extent of their burden is not adequately addressed in developed countries, including Japan. This systematic review was conducted to analyze time trends in the economic burden of in...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-04-01
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| Series: | Discover Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12982-025-00577-8 |
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| Summary: | Abstract Introduction Although infection-related cancers are largely preventable through vaccination and screening, the extent of their burden is not adequately addressed in developed countries, including Japan. This systematic review was conducted to analyze time trends in the economic burden of infection-related cancers in Japan. Methods We performed a systematic search on 14 cancers evidenced to be causally associated with five infectious agents, using PubMed and Scopus databases from their data inception to 2023. We selected English peer-reviewed articles that measured the monetary cost of infection-related cancers in Japan, regardless of cancer stage. Mixed methods of qualitative and quantitative analysis were conducted to thoroughly assess selected articles, following the PRISMA statement. Results Of the 820 documents initially included, 10 articles were retrieved for the final analysis. Most studies focused on the financial burden of stomach, liver, and cervical cancers. The total cost of three major infection-related cancers decreased significantly from 1746.2 billion yen (16,052.5 million USD) in 1996 to 885.9 billion yen (8297 million USD) in 2020. While the costs of stomach and liver cancers attributed to infections (Helicobacter pylori and Hepatitis B/Hepatitis C viruses) observed downward trends, the cost of cervical cancer related to Human papillomavirus (HPV) exhibited an upward trend. Conclusion Despite decreasing trends in the overall costs of infection-related cancers, the economic burden of HPV-related cervical cancer steadily increases in Japan. Alongside ongoing prevention for infection cancers in general, it is imperative to prioritize HPV vaccinations and related screening programs as a key focus in Japanese public health policy. |
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| ISSN: | 3005-0774 |