FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer

FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer

Abstract Background Dysregulated energy metabolism has emerged as a defining hallmark of cancer, particularly evident in triple-negative breast cancer (TNBC). Distinct from other breast cancer subtypes, TNBC exhibits heightened glycolysis and aggressiveness. However, the transcriptional mechanisms o...

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Bibliographic Details
Main Authors: Gang Zhao, Yutong Liu, Shiqi Yin, Runxiang Cao, Qian Zhao, Yifan Fu, Ye Du
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Energy metabolism
Drug resistance
Glucose metabolism
Glucose transporter
Gene promoter
Online Access:https://doi.org/10.1186/s12967-024-06014-9
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