Psycho-oncological burden in patients with brain metastases undergoing neurological surgery
PurposeThe development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1463467/full |
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| author | Tommaso Araceli Tommaso Araceli Anna Fischl Anna Fischl Amer Haj Amer Haj Christian Doenitz Christian Doenitz Eva-Maria Stoerr Andrea Hillberg Andrea Hillberg Martin Vogelhuber Martin Vogelhuber Katharina Rosengarth Katharina Rosengarth Markus J. Riemenschneider Markus J. Riemenschneider Peter Hau Peter Hau Raquel Blazquez Raquel Blazquez Tobias Pukrop Tobias Pukrop Tobias Pukrop Elisabeth Bumes Elisabeth Bumes Nils Ole Schmidt Nils Ole Schmidt Martin Proescholdt Martin Proescholdt |
| author_facet | Tommaso Araceli Tommaso Araceli Anna Fischl Anna Fischl Amer Haj Amer Haj Christian Doenitz Christian Doenitz Eva-Maria Stoerr Andrea Hillberg Andrea Hillberg Martin Vogelhuber Martin Vogelhuber Katharina Rosengarth Katharina Rosengarth Markus J. Riemenschneider Markus J. Riemenschneider Peter Hau Peter Hau Raquel Blazquez Raquel Blazquez Tobias Pukrop Tobias Pukrop Tobias Pukrop Elisabeth Bumes Elisabeth Bumes Nils Ole Schmidt Nils Ole Schmidt Martin Proescholdt Martin Proescholdt |
| author_sort | Tommaso Araceli |
| collection | DOAJ |
| description | PurposeThe development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine. Therefore, we analyzed the extent of psycho-oncological distress in a patient population with BM receiving neurosurgical resection and identified clinical characteristics associated with a high need for psycho-oncological intervention.MethodsWe prospectively screened 353 patients (169 female, 184 male, mean age 61.9 years) scheduled for microsurgical resection of one or more BM. Psycho-oncological screening was performed on the day of admission using the Hornheider screening instrument (HSI) and the distress thermometer (DT). Screening results were correlated with demographic and clinical data.ResultsMost patients (73.1%) completed the screening questionnaire. Patients who failed to complete the questionnaire presented more frequently with metachronous BM (74.7% vs. 25.3%, p=0.009), were significantly older (p=0.0018), and had a significantly lower KPS score (p=0.0002). Based on the threshold values of the questionnaires, 59.3% of the patients showed a significant psycho-oncological burden requiring immediate intervention. Univariate analysis demonstrated that synchronous BM (p=0.034), tumors in eloquent areas (p=0.001), lower KPS (p=0.031), female gender (p=0.009), and presurgical aphasia (p=0.042) were significantly associated with high psycho-oncological burden. Multivariate analysis showed synchronous BM (p=0.045), female gender (p=0.005), and lower KPS (p=0.028) as independent factors associated with high psycho-oncological burden.ConclusionThe majority of patients with BM have a high psycho-oncological burden. Female gender, synchronous BM, and lower KPS are independently associated with a need for psycho-oncological intervention. |
| format | Article |
| id | doaj-art-c8cf9573ddbc436d94ab5fa507e94d69 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c8cf9573ddbc436d94ab5fa507e94d692024-11-28T06:33:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14634671463467Psycho-oncological burden in patients with brain metastases undergoing neurological surgeryTommaso Araceli0Tommaso Araceli1Anna Fischl2Anna Fischl3Amer Haj4Amer Haj5Christian Doenitz6Christian Doenitz7Eva-Maria Stoerr8Andrea Hillberg9Andrea Hillberg10Martin Vogelhuber11Martin Vogelhuber12Katharina Rosengarth13Katharina Rosengarth14Markus J. Riemenschneider15Markus J. Riemenschneider16Peter Hau17Peter Hau18Raquel Blazquez19Raquel Blazquez20Tobias Pukrop21Tobias Pukrop22Tobias Pukrop23Elisabeth Bumes24Elisabeth Bumes25Nils Ole Schmidt26Nils Ole Schmidt27Martin Proescholdt28Martin Proescholdt29Department of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurology, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Internal Medicine III, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Internal Medicine III, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neuropathology, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurology, Regensburg University Medical Center, Regensburg, GermanyDepartment of Internal Medicine III, Regensburg University Medical Center, Regensburg, GermanyBavarian Cancer Research Center (BZKF), Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Internal Medicine III, Regensburg University Medical Center, Regensburg, GermanyBavarian Cancer Research Center (BZKF), Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurology, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyDepartment of Neurosurgery, Regensburg University Medical Center, Regensburg, GermanyWilhelm Sander-NeuroOncology Unit, Regensburg University Medical Center, Regensburg, GermanyPurposeThe development of brain metastases (BM) can significantly increase the psycho-oncological burden in cancer patients, requiring timely intervention. In addition, this aspect may negatively affect the course of the disease and treatment outcome. However, screening for psycho-oncological burden is often overlooked in clinical routine. Therefore, we analyzed the extent of psycho-oncological distress in a patient population with BM receiving neurosurgical resection and identified clinical characteristics associated with a high need for psycho-oncological intervention.MethodsWe prospectively screened 353 patients (169 female, 184 male, mean age 61.9 years) scheduled for microsurgical resection of one or more BM. Psycho-oncological screening was performed on the day of admission using the Hornheider screening instrument (HSI) and the distress thermometer (DT). Screening results were correlated with demographic and clinical data.ResultsMost patients (73.1%) completed the screening questionnaire. Patients who failed to complete the questionnaire presented more frequently with metachronous BM (74.7% vs. 25.3%, p=0.009), were significantly older (p=0.0018), and had a significantly lower KPS score (p=0.0002). Based on the threshold values of the questionnaires, 59.3% of the patients showed a significant psycho-oncological burden requiring immediate intervention. Univariate analysis demonstrated that synchronous BM (p=0.034), tumors in eloquent areas (p=0.001), lower KPS (p=0.031), female gender (p=0.009), and presurgical aphasia (p=0.042) were significantly associated with high psycho-oncological burden. Multivariate analysis showed synchronous BM (p=0.045), female gender (p=0.005), and lower KPS (p=0.028) as independent factors associated with high psycho-oncological burden.ConclusionThe majority of patients with BM have a high psycho-oncological burden. Female gender, synchronous BM, and lower KPS are independently associated with a need for psycho-oncological intervention.https://www.frontiersin.org/articles/10.3389/fonc.2024.1463467/fullpsycho-oncologybrain tumorneurosurgerypsychological distresspsycho-oncological need |
| spellingShingle | Tommaso Araceli Tommaso Araceli Anna Fischl Anna Fischl Amer Haj Amer Haj Christian Doenitz Christian Doenitz Eva-Maria Stoerr Andrea Hillberg Andrea Hillberg Martin Vogelhuber Martin Vogelhuber Katharina Rosengarth Katharina Rosengarth Markus J. Riemenschneider Markus J. Riemenschneider Peter Hau Peter Hau Raquel Blazquez Raquel Blazquez Tobias Pukrop Tobias Pukrop Tobias Pukrop Elisabeth Bumes Elisabeth Bumes Nils Ole Schmidt Nils Ole Schmidt Martin Proescholdt Martin Proescholdt Psycho-oncological burden in patients with brain metastases undergoing neurological surgery Frontiers in Oncology psycho-oncology brain tumor neurosurgery psychological distress psycho-oncological need |
| title | Psycho-oncological burden in patients with brain metastases undergoing neurological surgery |
| title_full | Psycho-oncological burden in patients with brain metastases undergoing neurological surgery |
| title_fullStr | Psycho-oncological burden in patients with brain metastases undergoing neurological surgery |
| title_full_unstemmed | Psycho-oncological burden in patients with brain metastases undergoing neurological surgery |
| title_short | Psycho-oncological burden in patients with brain metastases undergoing neurological surgery |
| title_sort | psycho oncological burden in patients with brain metastases undergoing neurological surgery |
| topic | psycho-oncology brain tumor neurosurgery psychological distress psycho-oncological need |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1463467/full |
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