Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer
Abstract Near‐infrared (NIR) photothermal therapy plays a critical role in the cancer treatment and diagnosis as a promising carcinoma treatment modalities nowadays. However, development of clinical application has been greatly limited due to the inefficient drug release and low tumor accumulation....
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Bioengineering & Translational Medicine |
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| Online Access: | https://doi.org/10.1002/btm2.10368 |
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| author | Taicheng Zhou Lili Wu Ning Ma Fuxin Tang Jialin Chen Zhipeng Jiang Yingru Li Tao Ma Na Yang Zhen Zong |
| author_facet | Taicheng Zhou Lili Wu Ning Ma Fuxin Tang Jialin Chen Zhipeng Jiang Yingru Li Tao Ma Na Yang Zhen Zong |
| author_sort | Taicheng Zhou |
| collection | DOAJ |
| description | Abstract Near‐infrared (NIR) photothermal therapy plays a critical role in the cancer treatment and diagnosis as a promising carcinoma treatment modalities nowadays. However, development of clinical application has been greatly limited due to the inefficient drug release and low tumor accumulation. Herein, we designed a NIR‐light triggered indocyanine green (ICG)‐based PCL core/P(MEO2MA‐b‐HMAM) shell nanocomposites (PPH@ICG) and evaluated their therapeutic effects in vitro and in vivo. The anticancer drug 5‐fluorouracil (5Fu) and the photothermal agent ICG were loaded into a thermo‐sensitive micelle (PPH@5Fu@ICG) by self‐assembly. The nanoparticles formed were characterized using transmission electron microscopy, dynamic light scattering, and fluorescence spectra. The thermo‐sensitive copolymer (PPH@5Fu@ICG) showed a great temperature‐controlled drug release response with lower critical solution temperature. In vitro cellular uptake and TEM imaging proved that PPH@5Fu@ICG nanoparticles can home into the lysosomal compartments under NIR. Moreover, in gastric tumor‐bearing nude mice, PPH@5Fu@ICG + NIR group exhibited excellent improvement in antitumor efficacy based on the NIR‐triggered thermo‐chemotherapy synergy, both in vitro and in vivo. In summary, the proposed strategy of synergistic photo‐hyperthermia chemotherapy effectively reduced the 5Fu dose, toxic or side effect, which could serve as a secure and efficient approach for cancer theranostics. |
| format | Article |
| id | doaj-art-c8c7dea33cef4d1e8d3e8b489e71fba5 |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-c8c7dea33cef4d1e8d3e8b489e71fba52024-11-21T05:16:03ZengWileyBioengineering & Translational Medicine2380-67612023-01-0181n/an/a10.1002/btm2.10368Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancerTaicheng Zhou0Lili Wu1Ning Ma2Fuxin Tang3Jialin Chen4Zhipeng Jiang5Yingru Li6Tao Ma7Na Yang8Zhen Zong9Department of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Medical Ultrasonics Third Affiliated Hospital of Sun Yat‐sen University, Guangdong Key Laboratory of Liver Disease Research Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery and Hernia Center The Sixth Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Clinical Laboratory Guangzhou First People's Hospital, School of Medicine, South China University of Technology Guangzhou Guangdong ChinaDepartment of Gastroenterological Surgery The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi ChinaAbstract Near‐infrared (NIR) photothermal therapy plays a critical role in the cancer treatment and diagnosis as a promising carcinoma treatment modalities nowadays. However, development of clinical application has been greatly limited due to the inefficient drug release and low tumor accumulation. Herein, we designed a NIR‐light triggered indocyanine green (ICG)‐based PCL core/P(MEO2MA‐b‐HMAM) shell nanocomposites (PPH@ICG) and evaluated their therapeutic effects in vitro and in vivo. The anticancer drug 5‐fluorouracil (5Fu) and the photothermal agent ICG were loaded into a thermo‐sensitive micelle (PPH@5Fu@ICG) by self‐assembly. The nanoparticles formed were characterized using transmission electron microscopy, dynamic light scattering, and fluorescence spectra. The thermo‐sensitive copolymer (PPH@5Fu@ICG) showed a great temperature‐controlled drug release response with lower critical solution temperature. In vitro cellular uptake and TEM imaging proved that PPH@5Fu@ICG nanoparticles can home into the lysosomal compartments under NIR. Moreover, in gastric tumor‐bearing nude mice, PPH@5Fu@ICG + NIR group exhibited excellent improvement in antitumor efficacy based on the NIR‐triggered thermo‐chemotherapy synergy, both in vitro and in vivo. In summary, the proposed strategy of synergistic photo‐hyperthermia chemotherapy effectively reduced the 5Fu dose, toxic or side effect, which could serve as a secure and efficient approach for cancer theranostics.https://doi.org/10.1002/btm2.10368chemotherapygastric cancernanocarriersphotothermal therapyphotothermally responsive |
| spellingShingle | Taicheng Zhou Lili Wu Ning Ma Fuxin Tang Jialin Chen Zhipeng Jiang Yingru Li Tao Ma Na Yang Zhen Zong Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer Bioengineering & Translational Medicine chemotherapy gastric cancer nanocarriers photothermal therapy photothermally responsive |
| title | Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer |
| title_full | Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer |
| title_fullStr | Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer |
| title_full_unstemmed | Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer |
| title_short | Photothermally responsive theranostic nanocomposites for near‐infrared light triggered drug release and enhanced synergism of photothermo‐chemotherapy for gastric cancer |
| title_sort | photothermally responsive theranostic nanocomposites for near infrared light triggered drug release and enhanced synergism of photothermo chemotherapy for gastric cancer |
| topic | chemotherapy gastric cancer nanocarriers photothermal therapy photothermally responsive |
| url | https://doi.org/10.1002/btm2.10368 |
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