Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition

Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition

Continuous vaso-occlusive and inflammatory processes cause extensive end-organ damage in adults with sickle cell disease (SCD), and there is little evidence that longterm hydroxyurea therapy prevents this. In initial trials, P-selectin blockade with crizanlizumab reduced SCD vaso-occlusive crisis f...

Full description

Saved in:
Bibliographic Details
Main Authors: Érica M. F. Gotardo, Lidiane S. Torres, Bruna Cunha Zaidan, Lucas F. S. Gushiken, Pâmela L. Brito, Flavia C. Leonardo, Claudia H. Pellizzon, John Millholland, Sergei Agoulnik, Jiri Kovarik, Fernando F. Costa, Nicola Conran
Format: Article
Language:English
Published: Ferrata Storti Foundation 2024-11-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11840
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://haematologica.org/article/view/11840

Similar Items