Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia
ObjectiveNegative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1477285/full |
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| author | Peiyun Zhang Lingyun Chen Qianqian Qin Chao Liu Haijiao Zhu Wenqing Hu Wenqing Hu Xinyu He Kaihong Tang Qi Yan Hongmei Shen Hongmei Shen |
| author_facet | Peiyun Zhang Lingyun Chen Qianqian Qin Chao Liu Haijiao Zhu Wenqing Hu Wenqing Hu Xinyu He Kaihong Tang Qi Yan Hongmei Shen Hongmei Shen |
| author_sort | Peiyun Zhang |
| collection | DOAJ |
| description | ObjectiveNegative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms, cognitive deficits, and serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in patients with schizophrenia.Materials and methodsForty male long-term institutionalized inpatients with schizophrenia were assigned to either a CCRT group (n = 20) or a control group (n = 20). The CCRT intervention consisted of 40 individual 40-min sessions over 8 weeks, conducted five times a week. Psychiatric symptoms, cognition, and serum levels of BDNF and GDNF were assessed at baseline, 4 weeks, and 8 weeks.ResultsCompared to the control group, the CCRT group exhibited decreased total Positive and Negative Syndrome Scale and negative subscale scores, as well as increased Montreal Cognitive Assessment and Repeatable Battery for the Assessment of Neuropsychological Status scores. Moreover, improvements in list recall were associated with reduced negative symptoms. Additionally, CCRT ameliorated the decrease in serum GDNF levels in patients with schizophrenia.ConclusionThe effectiveness of CCRT in alleviating negative symptoms was associated with improvements in list recall, and GDNF may play a role in the observed effects of CCRT in patients with schizophrenia. |
| format | Article |
| id | doaj-art-c8be2f77284c44feb59727b10bf3397c |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-c8be2f77284c44feb59727b10bf3397c2025-01-16T11:52:33ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14772851477285Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophreniaPeiyun Zhang0Lingyun Chen1Qianqian Qin2Chao Liu3Haijiao Zhu4Wenqing Hu5Wenqing Hu6Xinyu He7Kaihong Tang8Qi Yan9Hongmei Shen10Hongmei Shen11Laboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaDepartment of Psychology, University of California, Davis, Davis, CA, United StatesLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaLaboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaObjectiveNegative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms, cognitive deficits, and serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in patients with schizophrenia.Materials and methodsForty male long-term institutionalized inpatients with schizophrenia were assigned to either a CCRT group (n = 20) or a control group (n = 20). The CCRT intervention consisted of 40 individual 40-min sessions over 8 weeks, conducted five times a week. Psychiatric symptoms, cognition, and serum levels of BDNF and GDNF were assessed at baseline, 4 weeks, and 8 weeks.ResultsCompared to the control group, the CCRT group exhibited decreased total Positive and Negative Syndrome Scale and negative subscale scores, as well as increased Montreal Cognitive Assessment and Repeatable Battery for the Assessment of Neuropsychological Status scores. Moreover, improvements in list recall were associated with reduced negative symptoms. Additionally, CCRT ameliorated the decrease in serum GDNF levels in patients with schizophrenia.ConclusionThe effectiveness of CCRT in alleviating negative symptoms was associated with improvements in list recall, and GDNF may play a role in the observed effects of CCRT in patients with schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1477285/fullschizophreniacomputerized cognitive remediation therapynegative symptomscognitive impairmentsbrain-derived neurotrophic factorglial cell line-derived neurotrophic factor |
| spellingShingle | Peiyun Zhang Lingyun Chen Qianqian Qin Chao Liu Haijiao Zhu Wenqing Hu Wenqing Hu Xinyu He Kaihong Tang Qi Yan Hongmei Shen Hongmei Shen Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia Frontiers in Psychiatry schizophrenia computerized cognitive remediation therapy negative symptoms cognitive impairments brain-derived neurotrophic factor glial cell line-derived neurotrophic factor |
| title | Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia |
| title_full | Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia |
| title_fullStr | Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia |
| title_full_unstemmed | Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia |
| title_short | Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia |
| title_sort | enhanced computerized cognitive remediation therapy improved cognitive function negative symptoms and gdnf in male long term inpatients with schizophrenia |
| topic | schizophrenia computerized cognitive remediation therapy negative symptoms cognitive impairments brain-derived neurotrophic factor glial cell line-derived neurotrophic factor |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1477285/full |
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