Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea
Abstract Background Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03252-2 |
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| author | Liang Wang Yuanqi Wang Tiantian Jiao Linghao Xu Endong Ji Sakibur Rahman Tapu Yehong Liu Jiming Li |
| author_facet | Liang Wang Yuanqi Wang Tiantian Jiao Linghao Xu Endong Ji Sakibur Rahman Tapu Yehong Liu Jiming Li |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | Abstract Background Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and OSA remains unclear. The purpose of this study was to clarify whether CPAP can improve arterial stiffness and inflammatory factor levels in CHD patients with OSA, and to further improve prognosis. Method 59 patients with coronary heart disease complicated by moderate to severe sleep apnea were divided into a CPAP treatment group (CPAP + coronary heart disease standard treatment) and a control group (only coronary heart disease standard treatment). Peripheral blood test reports were collected and pulse wave velocity (PWV) measurements were performed for each patient at the beginning, 3 months, and 6 months of treatment. Results After 6 months of treatment, the CPAP group showed more significant improvement in the levels of inflammatory factors such as white blood cell (WBC), neutrophil (N), C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), and PWV than the control group. Conclusion After active treatment with CPAP, arterial stiffness and inflammatory cytokine levels in patients with coronary heart disease and OSA improved. This association should be given more attention in clinical practice, and sleep apnea should be actively treated. |
| format | Article |
| id | doaj-art-c8b17bf4870c45d58a9670b8671e4eb2 |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-c8b17bf4870c45d58a9670b8671e4eb22025-01-12T12:39:01ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011810.1186/s13019-024-03252-2Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apneaLiang Wang0Yuanqi Wang1Tiantian Jiao2Linghao Xu3Endong Ji4Sakibur Rahman Tapu5Yehong Liu6Jiming Li7Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji UniversitySchool of Medicine, Tongji UniversitySchool of Medicine, Tongji UniversityDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji UniversityDepartment of Emergency and Critical Care, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineSchool of Medicine, Tongji UniversityDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji UniversityDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji UniversityAbstract Background Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and OSA remains unclear. The purpose of this study was to clarify whether CPAP can improve arterial stiffness and inflammatory factor levels in CHD patients with OSA, and to further improve prognosis. Method 59 patients with coronary heart disease complicated by moderate to severe sleep apnea were divided into a CPAP treatment group (CPAP + coronary heart disease standard treatment) and a control group (only coronary heart disease standard treatment). Peripheral blood test reports were collected and pulse wave velocity (PWV) measurements were performed for each patient at the beginning, 3 months, and 6 months of treatment. Results After 6 months of treatment, the CPAP group showed more significant improvement in the levels of inflammatory factors such as white blood cell (WBC), neutrophil (N), C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), and PWV than the control group. Conclusion After active treatment with CPAP, arterial stiffness and inflammatory cytokine levels in patients with coronary heart disease and OSA improved. This association should be given more attention in clinical practice, and sleep apnea should be actively treated.https://doi.org/10.1186/s13019-024-03252-2Continuous positive airway pressureObstructive sleep apneaCoronary heart diseaseArterial stiffnessInflammatory factors |
| spellingShingle | Liang Wang Yuanqi Wang Tiantian Jiao Linghao Xu Endong Ji Sakibur Rahman Tapu Yehong Liu Jiming Li Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea Journal of Cardiothoracic Surgery Continuous positive airway pressure Obstructive sleep apnea Coronary heart disease Arterial stiffness Inflammatory factors |
| title | Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| title_full | Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| title_fullStr | Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| title_full_unstemmed | Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| title_short | Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| title_sort | effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea |
| topic | Continuous positive airway pressure Obstructive sleep apnea Coronary heart disease Arterial stiffness Inflammatory factors |
| url | https://doi.org/10.1186/s13019-024-03252-2 |
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