Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain

Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain

IntroductionMany forms of chronic pain remain refractory to existing pharmacotherapies and electrical neuromodulation. We have recently reported the clinical efficacy of a novel form of analgesic electrical neuromodulation that uses ultra low frequency (ULF™) biphasic current and studied its effects...

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Bibliographic Details
Main Authors: Martyn G. Jones, Liam A. Matthews, Scott Lempka, Nishant Verma, James P. Harris, Stephen B. McMahon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Neuroscience
Subjects:
thalamus
ULF™ neuromodulation
spinal cord stimulation
inhibition
neuropathic
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1512950/full
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