Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes
Reperfusion therapy, which substantially promotes the vessel recanalization rate and improves clinical outcomes, remains the most effective treatment of acute ischemic stroke (AIS). However, a substantial number of patients are either unsuitable for recanalization therapy or experience limited recov...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Brain Circulation |
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| Online Access: | https://journals.lww.com/10.4103/bc.bc_165_24 |
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| _version_ | 1841556971473338368 |
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| author | Min Zhao Yue Qiao Alexander Weiss Wenbo Zhao |
| author_facet | Min Zhao Yue Qiao Alexander Weiss Wenbo Zhao |
| author_sort | Min Zhao |
| collection | DOAJ |
| description | Reperfusion therapy, which substantially promotes the vessel recanalization rate and improves clinical outcomes, remains the most effective treatment of acute ischemic stroke (AIS). However, a substantial number of patients are either unsuitable for recanalization therapy or experience limited recovery postreperfusion. There is growing recognition that adjunctive neuroprotective therapies may further improve the outcomes in AIS patients by protecting brain tissue during ischemia. Recent advancements in neuroprotective approaches, including pharmacologic agents such as nerinetide edaravone, and uric acid, as well as nonpharmacological interventions, such as remote ischemic conditioning and normobaric hyperoxia, offer promising potentials in stroke care. This review provides an overview of the current neuroprotective therapies, examines recent clinical evidence, and discusses the strengths and weaknesses of certain clinical trials aimed at cerebral protection. |
| format | Article |
| id | doaj-art-c89f487a7c20437f96fcf8d3a6d907ec |
| institution | Kabale University |
| issn | 2455-4626 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj-art-c89f487a7c20437f96fcf8d3a6d907ec2025-01-07T05:14:06ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262024-12-0110429630210.4103/bc.bc_165_24Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomesMin ZhaoYue QiaoAlexander WeissWenbo ZhaoReperfusion therapy, which substantially promotes the vessel recanalization rate and improves clinical outcomes, remains the most effective treatment of acute ischemic stroke (AIS). However, a substantial number of patients are either unsuitable for recanalization therapy or experience limited recovery postreperfusion. There is growing recognition that adjunctive neuroprotective therapies may further improve the outcomes in AIS patients by protecting brain tissue during ischemia. Recent advancements in neuroprotective approaches, including pharmacologic agents such as nerinetide edaravone, and uric acid, as well as nonpharmacological interventions, such as remote ischemic conditioning and normobaric hyperoxia, offer promising potentials in stroke care. This review provides an overview of the current neuroprotective therapies, examines recent clinical evidence, and discusses the strengths and weaknesses of certain clinical trials aimed at cerebral protection.https://journals.lww.com/10.4103/bc.bc_165_24acute ischemic strokecerebral protectionclinical studyreperfusion therapy |
| spellingShingle | Min Zhao Yue Qiao Alexander Weiss Wenbo Zhao Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes Brain Circulation acute ischemic stroke cerebral protection clinical study reperfusion therapy |
| title | Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes |
| title_full | Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes |
| title_fullStr | Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes |
| title_full_unstemmed | Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes |
| title_short | Neuroprotective strategies in acute ischemic stroke: A narrative review of recent advances and clinical outcomes |
| title_sort | neuroprotective strategies in acute ischemic stroke a narrative review of recent advances and clinical outcomes |
| topic | acute ischemic stroke cerebral protection clinical study reperfusion therapy |
| url | https://journals.lww.com/10.4103/bc.bc_165_24 |
| work_keys_str_mv | AT minzhao neuroprotectivestrategiesinacuteischemicstrokeanarrativereviewofrecentadvancesandclinicaloutcomes AT yueqiao neuroprotectivestrategiesinacuteischemicstrokeanarrativereviewofrecentadvancesandclinicaloutcomes AT alexanderweiss neuroprotectivestrategiesinacuteischemicstrokeanarrativereviewofrecentadvancesandclinicaloutcomes AT wenbozhao neuroprotectivestrategiesinacuteischemicstrokeanarrativereviewofrecentadvancesandclinicaloutcomes |