EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT
Introduction Gastric Diffuse large B‐cell lymphoma (DLBCL) is the most common extra-nodal site of lymphoma’s involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes found in systemic DLBCL. Gastric complicati...
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PAGEPress Publications
2022-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://mjhid.org/index.php/mjhid/article/view/4784 |
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| author | Luca Guarnera Federico Meconi Roberto Secchi Maria Rosaria Pascale Fabiana Esposito Annagiulia Zizzari Vito Mario Rapisarda Manuela Rizzo Livio Pupo Maria Cantonetti |
| author_facet | Luca Guarnera Federico Meconi Roberto Secchi Maria Rosaria Pascale Fabiana Esposito Annagiulia Zizzari Vito Mario Rapisarda Manuela Rizzo Livio Pupo Maria Cantonetti |
| author_sort | Luca Guarnera |
| collection | DOAJ |
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Introduction Gastric Diffuse large B‐cell lymphoma (DLBCL) is the most common extra-nodal site of lymphoma’s involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes found in systemic DLBCL. Gastric complications such as bleeding, perforation and stenosis under chemotherapy are well documented. Methods We retrospectively analyzed 15 patients with newly diagnosed DLBCL with gastrointestinal involvement. Endoscopies were performed in these patients before and after treatment. Treatment consisted in cyclophosphamide low-dose pre-phase chemotherapy before conventional-dose chemotherapy. Results Endoscopy at staging detected ulcers in 12 patients (80%). After low-dose pre-phase chemotherapy GI ulcers healed in 91.6% of cases (1 ulcer detected). After the whole treatment (Low-dose pre-phase + chemotherapy) 9 patients (60%) achieved complete response, 4 patients (26.6%) partial response, 2 (13,3%) patients presented disease progression. The most frequent adverse event was neutropenia (73.3%); the most frequent non hematological adverse event was transaminases elevation (20%). Conclusion Cyclophosphamide low-dose pre-phase chemotherapy resulted a safe and effective way to prevent adverse events in systemic DLBCL with gastrointestinal involvement.
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| format | Article |
| id | doaj-art-c8949b5e718b4a5fbfe83fd9f88d659f |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c8949b5e718b4a5fbfe83fd9f88d659f2024-12-02T03:05:25ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062022-02-0114110.4084/MJHID.2022.017EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENTLuca Guarnera0Federico Meconi1Roberto Secchi2Maria Rosaria Pascale3Fabiana Esposito4Annagiulia Zizzari5Vito Mario Rapisarda6Manuela Rizzo7Livio Pupo8Maria Cantonetti9Hematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, ItalyHematology, Department of Biomedicine and Prevention, University Tor Vergara, Rome, Italy Introduction Gastric Diffuse large B‐cell lymphoma (DLBCL) is the most common extra-nodal site of lymphoma’s involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes found in systemic DLBCL. Gastric complications such as bleeding, perforation and stenosis under chemotherapy are well documented. Methods We retrospectively analyzed 15 patients with newly diagnosed DLBCL with gastrointestinal involvement. Endoscopies were performed in these patients before and after treatment. Treatment consisted in cyclophosphamide low-dose pre-phase chemotherapy before conventional-dose chemotherapy. Results Endoscopy at staging detected ulcers in 12 patients (80%). After low-dose pre-phase chemotherapy GI ulcers healed in 91.6% of cases (1 ulcer detected). After the whole treatment (Low-dose pre-phase + chemotherapy) 9 patients (60%) achieved complete response, 4 patients (26.6%) partial response, 2 (13,3%) patients presented disease progression. The most frequent adverse event was neutropenia (73.3%); the most frequent non hematological adverse event was transaminases elevation (20%). Conclusion Cyclophosphamide low-dose pre-phase chemotherapy resulted a safe and effective way to prevent adverse events in systemic DLBCL with gastrointestinal involvement. http://mjhid.org/index.php/mjhid/article/view/4784Low-dose pre-phase chemotherapyDiffuse Large B Cell Lymphoma with gastrointestinal involvementCyclophosphamide |
| spellingShingle | Luca Guarnera Federico Meconi Roberto Secchi Maria Rosaria Pascale Fabiana Esposito Annagiulia Zizzari Vito Mario Rapisarda Manuela Rizzo Livio Pupo Maria Cantonetti EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT Mediterranean Journal of Hematology and Infectious Diseases Low-dose pre-phase chemotherapy Diffuse Large B Cell Lymphoma with gastrointestinal involvement Cyclophosphamide |
| title | EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT |
| title_full | EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT |
| title_fullStr | EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT |
| title_full_unstemmed | EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT |
| title_short | EFFICACY AND SAFETY OF CYCLOPHOSPHAMIDE LOW-DOSE PRE-PHASE CHEMOTHERAPY IN DIFFUSE LARGE B CELL LYMPHOMA WITH GASTROINTESTINAL INVOLVEMENT |
| title_sort | efficacy and safety of cyclophosphamide low dose pre phase chemotherapy in diffuse large b cell lymphoma with gastrointestinal involvement |
| topic | Low-dose pre-phase chemotherapy Diffuse Large B Cell Lymphoma with gastrointestinal involvement Cyclophosphamide |
| url | http://mjhid.org/index.php/mjhid/article/view/4784 |
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