Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis
Abstract The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequ...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Journal of Extracellular Vesicles |
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| Online Access: | https://doi.org/10.1002/jev2.70028 |
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| author | Qimeng Liu Tianliang Ma Zheyu Zhang Jiangyu Nan Guanzhi Liu Yute Yang Yihe Hu Jie Xie |
| author_facet | Qimeng Liu Tianliang Ma Zheyu Zhang Jiangyu Nan Guanzhi Liu Yute Yang Yihe Hu Jie Xie |
| author_sort | Qimeng Liu |
| collection | DOAJ |
| description | Abstract The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequent loosening. Extracellular vesicles, carrying the surface components and regulatory molecules of their parent cells, embody the cellular characteristics and biological functions of these progenitors. In a pioneering approach to precisely inhibit the pyroptosis of local macrophages induced by wear particles, we have engineered fused extracellular vesicles (fEV) from M2 macrophages and human umbilical cord mesenchymal stem cells. These fEV boast the distinctive capability for targeted transport and immune evasion, collectively enhancing the anti‐pyroptosis effect of the therapeutic extracellular vesicles. Our research demonstrates the targeted, significant preventive and therapeutic potential of fEVs against periprosthetic osteolysis prompted by wear particles, highlighting its crucial clinical significance and application prospects. These findings suggest that extracellular vesicle fusion technology heralds a novel paradigm in the design and development of targeted extracellular vesicle‐based drug delivery systems. |
| format | Article |
| id | doaj-art-c890a3b50aee48e9af06d476c83ce6ed |
| institution | Kabale University |
| issn | 2001-3078 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj-art-c890a3b50aee48e9af06d476c83ce6ed2025-01-17T11:11:12ZengWileyJournal of Extracellular Vesicles2001-30782024-12-011312n/an/a10.1002/jev2.70028Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysisQimeng Liu0Tianliang Ma1Zheyu Zhang2Jiangyu Nan3Guanzhi Liu4Yute Yang5Yihe Hu6Jie Xie7Department of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedics The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou ChinaAbstract The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequent loosening. Extracellular vesicles, carrying the surface components and regulatory molecules of their parent cells, embody the cellular characteristics and biological functions of these progenitors. In a pioneering approach to precisely inhibit the pyroptosis of local macrophages induced by wear particles, we have engineered fused extracellular vesicles (fEV) from M2 macrophages and human umbilical cord mesenchymal stem cells. These fEV boast the distinctive capability for targeted transport and immune evasion, collectively enhancing the anti‐pyroptosis effect of the therapeutic extracellular vesicles. Our research demonstrates the targeted, significant preventive and therapeutic potential of fEVs against periprosthetic osteolysis prompted by wear particles, highlighting its crucial clinical significance and application prospects. These findings suggest that extracellular vesicle fusion technology heralds a novel paradigm in the design and development of targeted extracellular vesicle‐based drug delivery systems.https://doi.org/10.1002/jev2.70028aseptic looseningfused extracellular vesiclesmacrophage pyroptosisperiprosthetic osteolysistargeted therapy |
| spellingShingle | Qimeng Liu Tianliang Ma Zheyu Zhang Jiangyu Nan Guanzhi Liu Yute Yang Yihe Hu Jie Xie Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis Journal of Extracellular Vesicles aseptic loosening fused extracellular vesicles macrophage pyroptosis periprosthetic osteolysis targeted therapy |
| title | Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| title_full | Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| title_fullStr | Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| title_full_unstemmed | Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| title_short | Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| title_sort | fused extracellular vesicles from m2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis |
| topic | aseptic loosening fused extracellular vesicles macrophage pyroptosis periprosthetic osteolysis targeted therapy |
| url | https://doi.org/10.1002/jev2.70028 |
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