Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions

Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions

Abstract Background Inadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organ...

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Main Authors: Samira Nekoufar, Marjan Ghorbani, Sahar Safaei, Gholamreza Alinezhadi Khosroushahi, Farzad Izak Shirian, Behzad Baradaran, Masoumeh Tavakoli-Yaraki
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Gemcitabine
Metal–organic frameworks
Apoptosis
Cell cycle
Cell migration
MIA-PaCa-2
Online Access:https://doi.org/10.1186/s12885-024-13397-x
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