Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study
BackgroundThis study aimed to investigate the association between serum heat shock protein 27 (HSP27) levels and 28-day mortality in patients with sepsis.MethodsThis retrospective study analyzed the clinical data of 76 septic patients admitted to the intensive care unit (ICU). Fifty non-septic ICU p...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1513788/full |
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| author | Lihua Yao Lihua Yao Zaiwei Fan Fangyi Yao Xiaozhong Wang |
| author_facet | Lihua Yao Lihua Yao Zaiwei Fan Fangyi Yao Xiaozhong Wang |
| author_sort | Lihua Yao |
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| description | BackgroundThis study aimed to investigate the association between serum heat shock protein 27 (HSP27) levels and 28-day mortality in patients with sepsis.MethodsThis retrospective study analyzed the clinical data of 76 septic patients admitted to the intensive care unit (ICU). Fifty non-septic ICU patients and 50 healthy individuals served as control groups. Serum HSP27 levels were measured on the day of ICU admission and compared to sepsis severity and survival outcomes.ResultsMedian serum HSP27 levels in septic patients (4.70 ng/mL, IQR: 2.10–13.48 ng/mL) were significantly higher than those in both non-septic ICU controls and healthy controls (all p < 0.05). Moreover, non-survivors exhibited significantly higher median HSP27 levels (9.30 ng/mL, IQR: 3.62–25.91 ng/mL) compared to survivors (3.03 ng/mL, IQR: 1.48–7.39 ng/mL, p < 0.05). Multivariate logistic regression analysis confirmed the association between HSP27 levels and 28-day mortality in sepsis patients. Receiver operating characteristic (ROC) curve analysis revealed an area under the curve (AUC) of 0.720 (95% CI: 0.605–0.817, p < 0.001) for HSP27 in predicting sepsis prognosis. Survival analysis demonstrated that patients with high serum HSP27 levels (≥2.61 ng/mL) had a worse prognosis than those with low levels (<2.61 ng/mL).ConclusionHSP27 shows potential as a biomarker for the diagnosis and prognosis of sepsis, however, further research is necessary to solidify its clinical utility. |
| format | Article |
| id | doaj-art-c84457f5fdb6420fb6bd0a6a616fa7d2 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-c84457f5fdb6420fb6bd0a6a616fa7d22025-01-09T12:40:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15137881513788Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort studyLihua Yao0Lihua Yao1Zaiwei Fan2Fangyi Yao3Xiaozhong Wang4Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaBackgroundThis study aimed to investigate the association between serum heat shock protein 27 (HSP27) levels and 28-day mortality in patients with sepsis.MethodsThis retrospective study analyzed the clinical data of 76 septic patients admitted to the intensive care unit (ICU). Fifty non-septic ICU patients and 50 healthy individuals served as control groups. Serum HSP27 levels were measured on the day of ICU admission and compared to sepsis severity and survival outcomes.ResultsMedian serum HSP27 levels in septic patients (4.70 ng/mL, IQR: 2.10–13.48 ng/mL) were significantly higher than those in both non-septic ICU controls and healthy controls (all p < 0.05). Moreover, non-survivors exhibited significantly higher median HSP27 levels (9.30 ng/mL, IQR: 3.62–25.91 ng/mL) compared to survivors (3.03 ng/mL, IQR: 1.48–7.39 ng/mL, p < 0.05). Multivariate logistic regression analysis confirmed the association between HSP27 levels and 28-day mortality in sepsis patients. Receiver operating characteristic (ROC) curve analysis revealed an area under the curve (AUC) of 0.720 (95% CI: 0.605–0.817, p < 0.001) for HSP27 in predicting sepsis prognosis. Survival analysis demonstrated that patients with high serum HSP27 levels (≥2.61 ng/mL) had a worse prognosis than those with low levels (<2.61 ng/mL).ConclusionHSP27 shows potential as a biomarker for the diagnosis and prognosis of sepsis, however, further research is necessary to solidify its clinical utility.https://www.frontiersin.org/articles/10.3389/fmed.2024.1513788/fullHSP27sepsisprognosisinfectioninflammatory |
| spellingShingle | Lihua Yao Lihua Yao Zaiwei Fan Fangyi Yao Xiaozhong Wang Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study Frontiers in Medicine HSP27 sepsis prognosis infection inflammatory |
| title | Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study |
| title_full | Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study |
| title_fullStr | Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study |
| title_full_unstemmed | Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study |
| title_short | Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study |
| title_sort | prognostic value of hsp27 in 28 day mortality in septic icu patients a retrospective cohort study |
| topic | HSP27 sepsis prognosis infection inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1513788/full |
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