Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission

Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission

Abstract Schizophrenia is a severe neuropsychiatric disease, but the initiation mechanisms are unclear. Although antipsychotics are effective against positive symptoms, therapeutic interventions for negative symptoms are limited due to the lack of pathophysiological mechanisms. Here we identify syna...

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Main Authors: Yang Chen, Yuhao Gu, Bianbian Wang, Anqi Wei, Nan Dong, Yong Jiang, Xiaoying Liu, Li Zhu, Feng Zhu, Tao Tan, Zexin Jing, Fenghan Mao, Yichi Zhang, Jingyu Yao, Yuxin Yang, Hongyan Wang, Hao Wu, Hua Li, Chaowen Zheng, Xueting Duan, Jingxiao Huo, Xuanang Wu, Shaoqin Hu, Anran Zhao, Ziyang Li, Xu Cheng, Yuhao Qin, Qian Song, Shuqin Zhan, Qiumin Qu, Fanglin Guan, Huadong Xu, Xinjiang Kang, Changhe Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54604-4
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