Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review

Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review

Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectivene...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gengda Huang, Hong He, Yuting Fan, Qinqin Ren, Huixin Jiang, Li Luo, Li Guo, Haiwen Chen, Jiexia Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	non-small cell lung cancer Epstein-Barr virus lymphoepithelioma-like carcinoma induction chemotherapy radical radiotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605900/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparative analysis of antiangiogenic and immunotherapeutic regimens in the treatment of metastatic pulmonary lymphoepithelioma-like carcinoma
by: Fu-Lian Qu, et al.
Published: (2025-07-01)

Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma
by: Yi Que, et al.
Published: (2024-12-01)

Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases
by: Sachi Kawagishi, et al.
Published: (2019-10-01)

Immunological Prevalence of EBV in Rheumatoid Arthritis Iraqi Patients
by: Wafaa Ayad Al-Nuaimy, et al.
Published: (2025-07-01)

Advancements in the epidemiology of nasopharyngeal carcinoma
by: DU Yun, et al.
Published: (2024-09-01)

Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome
by: Leonardo Josué Castro-Muñoz, et al.
Published: (2025-08-01)

CLINICAL-IMMUNOLOGY EFFICIENCY OF CONSERVATIVE TREATMENT OF PATIENTS WITH CHRONIC TONSILLITIS ASSOCIATED WITH EPSTEIN - BARR VIRUS INFECTION
by: A. S. Krasnitskaja, et al.
Published: (2012-05-01)

Prognostic implications of EBER and EBV DNA combinations in nasopharyngeal carcinoma in endemic areas
by: Ying Li, et al.
Published: (2025-08-01)

Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix
by: Diana Strateva, et al.
Published: (2020-12-01)

serologic markers of Epstein-Barr virus reactivation in the conditions of viral encephalitis in young patients
by: O. V. Goleva, et al.
Published: (2015-04-01)

The Role of Epstein-Barr Virus in the Pathogenesis of Autoimmune Diseases
by: Natalia Morawiec, et al.
Published: (2025-06-01)

A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
by: Yuki Katsura, et al.
Published: (2021-11-01)

Cytomegalovirus and Epstein-Barr virus infections among Jordanians: seroprevalence and associated factors
by: Hassan M. Kofahi, et al.
Published: (2025-05-01)

Molecular diagnosis of nasopharyngeal carcinoma: Past and future
by: Cheng-Lung Hsu, et al.
Published: (2025-02-01)

Epstein-Barr virus in Adygeans and Slavs in Russia: virus types, <i>LMP1</i> variants, and malignant tumors
by: K. V. Smirnova, et al.
Published: (2022-10-01)

Seasonality of infection caused by Epstein – Barr virus
by: T. V. Solomay, et al.
Published: (2020-10-01)

Histopathological characteristics of Epstein-Barr virus (EBV)–associated encephalitis and colitis in chronic active EBV infection
by: Betty A Kasimo, et al.
Published: (2025-05-01)

Case Report: Epstein-Barr virus negative lymphoepithelioma-like cholangiocarcinoma: a rare tumor that deserves further exploration. Report of a case with distinct genomic and clinical features
by: Salvatore Corallo, et al.
Published: (2025-08-01)

About features clinical acute Epstein-Barr virus infection in children syndrome undifferentiated Connective tissue dysplasia
by: S. N. Orlova, et al.
Published: (2014-09-01)

Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: an effective treatment modality case report
by: Pei Yuan Fong, et al.
Published: (2021-01-01)

Cytotoxic Lesions of the Corpus Callosum (CLOCCs) in a Patient with Epstein–Barr Infection: A Case Report and Literature Review
by: Ilona Kopyta, et al.
Published: (2025-02-01)

Case Report: Uncommon presentation of Ewing sarcoma complicated by hemophagocytic lymphohistiocytosis: a diagnostic dilemma and therapeutic challenge
by: Zhuan Zou, et al.
Published: (2025-08-01)

Research progress of oral hairy leukoplakia
by: MO Longhui, LIANG Jing, WANG Jiongke, LIU Tiannan, ZENG Xin
Published: (2025-08-01)

Comparison between ELISA and PCR for Detection of Epstein - Barr virus in children with acute cervical lymphadenitis
by: Nazim Khan, et al.
Published: (2024-11-01)

Role of viral infection in the etiopathogenesis of breast cancer
by: L. A. Ashrafyan, et al.
Published: (2014-08-01)

EBV status has prognostic implication among young patients with angioimmunoblastic T‐cell lymphoma
by: Ahmed E. Eladl, et al.
Published: (2020-01-01)

Diagnostic Value of the Laboratory Markers of Acute Cytomegalovirus Infection in Patients With Systemic Lupus Erythematosus
by: Abrahamovych U., et al.
Published: (2019-12-01)

A case of coexistence of hydroa vacciniforme-like lymphoproliferative disorder and Epstein-Barr virus pneumonia
by: Wei Zhang, MD, PhD, et al.
Published: (2025-09-01)

Anti-EBV: Artificial intelligence driven predictive modeling for repurposing drugs as potential antivirals against Epstein-Barr virus
by: Hiteshi Vaidya, et al.
Published: (2025-01-01)

Correction: EBV-positive diffuse large B cell lymphoma secondary to activated phosphoinositide 3 kinase δ syndrome type 1 (APDS1): a case report and literature review
by: Qiu-yuan Xiang, et al.
Published: (2025-07-01)

Beyond the ratio of tumor reduction: residual volume after induction chemotherapy emerges as the optimal biomarker in advanced nasopharyngeal cancer
by: Sixue Dong, et al.
Published: (2025-06-01)

Diagnostic significance of DNA and antibodies against capsid antigens of anti-Epstein–Barr virus antibodies levels in blood plasma of nasopharyngeal carcinoma patients from non-endemic region
by: V. E. Gurtsevich, et al.
Published: (2015-06-01)

High pretreatment plasma Epstein‐Barr virus (EBV) DNA level is a poor prognostic marker in HIV‐associated, EBV‐negative diffuse large B‐cell lymphoma in Malawi
by: Nathan D. Montgomery, et al.
Published: (2020-01-01)

The role of cycloferon in the treatment of chronic Helicobacter pyloriinduced gastritis with gastric erosions associated with Epstein – Barr virus
by: T. E. Afanasenkova, et al.
Published: (2022-02-01)

mSphere of Influence: The integral art of resolving host-virus interactions
by: Elliott D. SoRelle
Published: (2025-04-01)

Optic disc vasculitis secondary to mononucleosis: a case report
by: N. A. Voroshilova, et al.
Published: (2024-10-01)

Diagnostic criteria for Epstein-barr virus-associated encephalitis: a comment on Liu et al
by: Fereshte Sheybani, et al.
Published: (2025-07-01)

The PD-1/PD-L1 pathway and Epstein–Barr virus
by: Hui Wang, et al.
Published: (2025-06-01)

Mini-review on the therapeutic vaccines targeting chronic infectious diseases: Evaluation system of therapeutic vaccines targeting HPV and EBV-related cancers
by: Seungkyun Woo, et al.
Published: (2025-12-01)

Elevated CD4⁺/CD8⁺ ratio and D-dimer as diagnostic biomarkers for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis versus infectious mononucleosis in children: a retrospective case-control study
by: Yun Cheng, et al.
Published: (2025-08-01)