The therapeutic potential of vitamins A, C, and D in pancreatic cancer
The pancreatic ductal adenocarcinoma (PDAC) is among the deadliest tumor diseases worldwide. While treatment options have generally become more diverse, little progress has been made in the treatment of PDAC and the median survival time for patients with locally advanced PDAC is between 8.7 and 13.7...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024176293 |
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| author | Alban Piotrowsky Markus Burkard Hendrik Schmieder Sascha Venturelli Olga Renner Luigi Marongiu |
| author_facet | Alban Piotrowsky Markus Burkard Hendrik Schmieder Sascha Venturelli Olga Renner Luigi Marongiu |
| author_sort | Alban Piotrowsky |
| collection | DOAJ |
| description | The pancreatic ductal adenocarcinoma (PDAC) is among the deadliest tumor diseases worldwide. While treatment options have generally become more diverse, little progress has been made in the treatment of PDAC and the median survival time for patients with locally advanced PDAC is between 8.7 and 13.7 months despite treatment. The aim of this review was to explore the therapeutic potential of complementing standard therapy with natural or synthetic forms of vitamins A, C, and D.The therapeutic use of vitamins A, C, and D could be a promising addition to the treatment of PDAC. For all three vitamins and their derivatives, tumor cell-specific cytotoxicity and growth inhibition against PDAC cells has been demonstrated in vitro and in preclinical animal models. While the antitumor effect of vitamin C is probably mainly due to its pro-oxidative effect in supraphysiological concentrations, vitamin A and vitamin D exert their effect by activating nuclear receptors and influencing gene transcription. In addition, there is increasing evidence that vitamin A and vitamin D influence the tumor stroma, making the tumor tissue more accessible to other therapeutic agents.Based on these promising findings, there is a high urgency to investigate vitamins A, C, and D in a clinical context as a supplement to standard therapy in PDAC. Further studies are needed to better understand the exact mechanism of action of the individual compounds and to develop the best possible treatment regimen. This could contribute to the long-awaited progress in the treatment of this highly lethal tumor entity. |
| format | Article |
| id | doaj-art-c80645b7c01d4bbe86060e240403f0c5 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj-art-c80645b7c01d4bbe86060e240403f0c52025-01-17T04:51:43ZengElsevierHeliyon2405-84402025-01-01111e41598The therapeutic potential of vitamins A, C, and D in pancreatic cancerAlban Piotrowsky0Markus Burkard1Hendrik Schmieder2Sascha Venturelli3Olga Renner4Luigi Marongiu5Department of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, GermanyDepartment of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, GermanyDepartment of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, GermanyDepartment of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, Germany; Institute of Physiology, Department of Vegetative and Clinical Physiology, University Hospital Tuebingen, 72076, Tuebingen, GermanyDepartment of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, Germany; Faculty of Food and Nutrition Sciences, University of Applied Sciences, Hochschule Niederrhein, 41065, Moenchengladbach, Germany; Corresponding author. Department of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, Germany.olga.renner@hs-niederrhein.deDepartment of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, Germany; HoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheim, 70599, Stuttgart, Germany; Corresponding author. Department of Nutritional Biochemistry, University of Hohenheim, 70599, Stuttgart, Germany.luigi.marongiu@uni-hohenheim.deThe pancreatic ductal adenocarcinoma (PDAC) is among the deadliest tumor diseases worldwide. While treatment options have generally become more diverse, little progress has been made in the treatment of PDAC and the median survival time for patients with locally advanced PDAC is between 8.7 and 13.7 months despite treatment. The aim of this review was to explore the therapeutic potential of complementing standard therapy with natural or synthetic forms of vitamins A, C, and D.The therapeutic use of vitamins A, C, and D could be a promising addition to the treatment of PDAC. For all three vitamins and their derivatives, tumor cell-specific cytotoxicity and growth inhibition against PDAC cells has been demonstrated in vitro and in preclinical animal models. While the antitumor effect of vitamin C is probably mainly due to its pro-oxidative effect in supraphysiological concentrations, vitamin A and vitamin D exert their effect by activating nuclear receptors and influencing gene transcription. In addition, there is increasing evidence that vitamin A and vitamin D influence the tumor stroma, making the tumor tissue more accessible to other therapeutic agents.Based on these promising findings, there is a high urgency to investigate vitamins A, C, and D in a clinical context as a supplement to standard therapy in PDAC. Further studies are needed to better understand the exact mechanism of action of the individual compounds and to develop the best possible treatment regimen. This could contribute to the long-awaited progress in the treatment of this highly lethal tumor entity.http://www.sciencedirect.com/science/article/pii/S2405844024176293VitaminsCancerPancreatic cancerAscorbic acidCalcitriolATRA |
| spellingShingle | Alban Piotrowsky Markus Burkard Hendrik Schmieder Sascha Venturelli Olga Renner Luigi Marongiu The therapeutic potential of vitamins A, C, and D in pancreatic cancer Heliyon Vitamins Cancer Pancreatic cancer Ascorbic acid Calcitriol ATRA |
| title | The therapeutic potential of vitamins A, C, and D in pancreatic cancer |
| title_full | The therapeutic potential of vitamins A, C, and D in pancreatic cancer |
| title_fullStr | The therapeutic potential of vitamins A, C, and D in pancreatic cancer |
| title_full_unstemmed | The therapeutic potential of vitamins A, C, and D in pancreatic cancer |
| title_short | The therapeutic potential of vitamins A, C, and D in pancreatic cancer |
| title_sort | therapeutic potential of vitamins a c and d in pancreatic cancer |
| topic | Vitamins Cancer Pancreatic cancer Ascorbic acid Calcitriol ATRA |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024176293 |
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