Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study
PurposeTo investigate static and dynamic brain functional alterations in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).Materials and methodsFifty-seven thyroid-associated ophthalmo...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1530967/full |
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| author | Jinling Lu Hao Hu Jiang Zhou Wenhao Jiang Xiongying Pu Huanhuan Chen Xiaoquan Xu Feiyun Wu |
| author_facet | Jinling Lu Hao Hu Jiang Zhou Wenhao Jiang Xiongying Pu Huanhuan Chen Xiaoquan Xu Feiyun Wu |
| author_sort | Jinling Lu |
| collection | DOAJ |
| description | PurposeTo investigate static and dynamic brain functional alterations in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).Materials and methodsFifty-seven thyroid-associated ophthalmopathy (TAO) patients (23 DON and 34 non-DON) and 27 healthy controls (HCs) underwent rs-fMRI scans. Static and dynamic ALFF (sALFF and dALFF) and ReHo (sReHo and dReHo) values were compared between groups. The support-vector machine (SVM) classification method was used to examine the diagnostic performance of the identified models.ResultsCompared to non-DON patients, DON patients showed decreased sALFF in the bilateral lingual gyrus (LING) and right cuneus (CUN), alongside increased sALFF in the bilateral medial part of the superior frontal gyrus, right dorsolateral part of the superior frontal gyrus (SFGdor), and right precentral gyrus. DON patients also exhibited decreased dALFF in the left LING and right CUN, together with increased dALFF in the right orbital part of the middle frontal gyrus and right SFGdor in comparison to non-DON patients. Meanwhile, DON patients had lower sReHo in the right LING, and higher sReHo and dReHo in the right supramarginal gyrus compared to non-DON patients. When detecting DON, the dALFF model showed optimal diagnostic performance (AUC 0.9987).ConclusionDysthyroid optic neuropathy patients exhibited both static and dynamic brain functional alterations in visual, cognitive, and emotion-related brain regions, deepening our current understanding of the underlying neural mechanisms of this disease. Rs-fMRI-based metrics, especially dALFF, may serve as relevant neuroimaging markers for diagnosing DON. |
| format | Article |
| id | doaj-art-c80467ec9b524f39a7c071d1534069d8 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-c80467ec9b524f39a7c071d1534069d82025-01-10T06:10:37ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.15309671530967Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI studyJinling Lu0Hao Hu1Jiang Zhou2Wenhao Jiang3Xiongying Pu4Huanhuan Chen5Xiaoquan Xu6Feiyun Wu7Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaPurposeTo investigate static and dynamic brain functional alterations in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).Materials and methodsFifty-seven thyroid-associated ophthalmopathy (TAO) patients (23 DON and 34 non-DON) and 27 healthy controls (HCs) underwent rs-fMRI scans. Static and dynamic ALFF (sALFF and dALFF) and ReHo (sReHo and dReHo) values were compared between groups. The support-vector machine (SVM) classification method was used to examine the diagnostic performance of the identified models.ResultsCompared to non-DON patients, DON patients showed decreased sALFF in the bilateral lingual gyrus (LING) and right cuneus (CUN), alongside increased sALFF in the bilateral medial part of the superior frontal gyrus, right dorsolateral part of the superior frontal gyrus (SFGdor), and right precentral gyrus. DON patients also exhibited decreased dALFF in the left LING and right CUN, together with increased dALFF in the right orbital part of the middle frontal gyrus and right SFGdor in comparison to non-DON patients. Meanwhile, DON patients had lower sReHo in the right LING, and higher sReHo and dReHo in the right supramarginal gyrus compared to non-DON patients. When detecting DON, the dALFF model showed optimal diagnostic performance (AUC 0.9987).ConclusionDysthyroid optic neuropathy patients exhibited both static and dynamic brain functional alterations in visual, cognitive, and emotion-related brain regions, deepening our current understanding of the underlying neural mechanisms of this disease. Rs-fMRI-based metrics, especially dALFF, may serve as relevant neuroimaging markers for diagnosing DON.https://www.frontiersin.org/articles/10.3389/fnins.2024.1530967/fulldysthyroid optic neuropathyamplitude of low-frequency fluctuationregional homogeneitydynamic analysisresting state fMRI |
| spellingShingle | Jinling Lu Hao Hu Jiang Zhou Wenhao Jiang Xiongying Pu Huanhuan Chen Xiaoquan Xu Feiyun Wu Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study Frontiers in Neuroscience dysthyroid optic neuropathy amplitude of low-frequency fluctuation regional homogeneity dynamic analysis resting state fMRI |
| title | Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study |
| title_full | Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study |
| title_fullStr | Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study |
| title_full_unstemmed | Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study |
| title_short | Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study |
| title_sort | altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy a resting state fmri study |
| topic | dysthyroid optic neuropathy amplitude of low-frequency fluctuation regional homogeneity dynamic analysis resting state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1530967/full |
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