Interplay between JAK/STAT pathway and non-coding RNAs in different cancers
Progress in the identification of core multi-protein modules within JAK/STAT pathway has enabled researchers to develop a better understanding of the linchpin role of deregulated signaling cascade in carcinogenesis and metastasis. More excitingly, complex interplay between JAK/STAT pathway and non-c...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Non-coding RNA Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000830 |
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| author | Ammad Ahmad Farooqi Abay M. Shepetov Venera Rakhmetova Zharilkassimov Ruslan Aigul Almabayeva Saniya Saussakova Kaini Baigonova Kainish Baimaganbetova Kalmakhanov Sundetgali Gulnara Kapanova |
| author_facet | Ammad Ahmad Farooqi Abay M. Shepetov Venera Rakhmetova Zharilkassimov Ruslan Aigul Almabayeva Saniya Saussakova Kaini Baigonova Kainish Baimaganbetova Kalmakhanov Sundetgali Gulnara Kapanova |
| author_sort | Ammad Ahmad Farooqi |
| collection | DOAJ |
| description | Progress in the identification of core multi-protein modules within JAK/STAT pathway has enabled researchers to develop a better understanding of the linchpin role of deregulated signaling cascade in carcinogenesis and metastasis. More excitingly, complex interplay between JAK/STAT pathway and non-coding RNAs has been shown to reprogramme the outcome of signaling cascade and modulate immunological responses within tumor microenvironment. Wealth of information has comprehensively illustrated that most of this complexity regulates the re-shaping of the immunological responses. Increasingly sophisticated mechanistic insights have illuminated fundamental role of STAT-signaling in polarization of macrophages to M2 phenotype that promotes disease aggressiveness. Overall, JAK/STAT signaling drives different stages of cancer ranging from cancer metastasis to the reshaping of the tumor microenvironment. JAK/STAT signaling has also been found to play role in the regulation of infiltration and activity of natural killer cells and CD4/CD8 cells by PD-L1/PD-1 signaling. In this review, we have attempted to set spotlight on regulation of JAK/STAT pathway by microRNAs, long non-coding RNAs and circular RNAs in primary tumors and metastasizing tumors. Therefore, existing knowledge gaps need to be addressed to propel this fledgling field of research to the forefront and bring lncRNAs and circRNAs to the frontline of clinical practice. Leveraging the growing momentum will enable interdisciplinary researchers to gain transition from segmented view to a fairly detailed conceptual continuum. |
| format | Article |
| id | doaj-art-c803b02a6a8041719b1586a8ab0a1376 |
| institution | Kabale University |
| issn | 2468-0540 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-c803b02a6a8041719b1586a8ab0a13762024-12-13T11:00:18ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-12-019410091022Interplay between JAK/STAT pathway and non-coding RNAs in different cancersAmmad Ahmad Farooqi0Abay M. Shepetov1Venera Rakhmetova2Zharilkassimov Ruslan3Aigul Almabayeva4Saniya Saussakova5Kaini Baigonova6Kainish Baimaganbetova7Kalmakhanov Sundetgali8Gulnara Kapanova9Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan; Corresponding author.Department of Nephrology, Asfendiyarov Kazakh National Medical University, Tole Bi St 94, Almaty, 050000, KazakhstanMedical University of Astana, Astana, 010000, KazakhstanDepartment of Surgical Diseases with a Course of Cardio-thoracic Surgery and Maxillofacial Surgery, NJSC “Astana Medical University”, Astana, KazakhstanDepartment of Human Anatomy, NJSC “Astana Medical University”, Astana City, KazakhstanDepartment of Public Health and Management, NJSC “Astana Medical University”, Astana, KazakhstanAl-Farabi Kazakh National University, KazakhstanAl-Farabi Kazakh National University, KazakhstanAl-Farabi Kazakh National University, KazakhstanAl-Farabi Kazakh National University, Kazakhstan; Scientific Center of Anti-Infectious Drugs, 75 Al-Farabi Ave, Almaty, 050040, KazakhstanProgress in the identification of core multi-protein modules within JAK/STAT pathway has enabled researchers to develop a better understanding of the linchpin role of deregulated signaling cascade in carcinogenesis and metastasis. More excitingly, complex interplay between JAK/STAT pathway and non-coding RNAs has been shown to reprogramme the outcome of signaling cascade and modulate immunological responses within tumor microenvironment. Wealth of information has comprehensively illustrated that most of this complexity regulates the re-shaping of the immunological responses. Increasingly sophisticated mechanistic insights have illuminated fundamental role of STAT-signaling in polarization of macrophages to M2 phenotype that promotes disease aggressiveness. Overall, JAK/STAT signaling drives different stages of cancer ranging from cancer metastasis to the reshaping of the tumor microenvironment. JAK/STAT signaling has also been found to play role in the regulation of infiltration and activity of natural killer cells and CD4/CD8 cells by PD-L1/PD-1 signaling. In this review, we have attempted to set spotlight on regulation of JAK/STAT pathway by microRNAs, long non-coding RNAs and circular RNAs in primary tumors and metastasizing tumors. Therefore, existing knowledge gaps need to be addressed to propel this fledgling field of research to the forefront and bring lncRNAs and circRNAs to the frontline of clinical practice. Leveraging the growing momentum will enable interdisciplinary researchers to gain transition from segmented view to a fairly detailed conceptual continuum.http://www.sciencedirect.com/science/article/pii/S2468054024000830 |
| spellingShingle | Ammad Ahmad Farooqi Abay M. Shepetov Venera Rakhmetova Zharilkassimov Ruslan Aigul Almabayeva Saniya Saussakova Kaini Baigonova Kainish Baimaganbetova Kalmakhanov Sundetgali Gulnara Kapanova Interplay between JAK/STAT pathway and non-coding RNAs in different cancers Non-coding RNA Research |
| title | Interplay between JAK/STAT pathway and non-coding RNAs in different cancers |
| title_full | Interplay between JAK/STAT pathway and non-coding RNAs in different cancers |
| title_fullStr | Interplay between JAK/STAT pathway and non-coding RNAs in different cancers |
| title_full_unstemmed | Interplay between JAK/STAT pathway and non-coding RNAs in different cancers |
| title_short | Interplay between JAK/STAT pathway and non-coding RNAs in different cancers |
| title_sort | interplay between jak stat pathway and non coding rnas in different cancers |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000830 |
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