Research advances in understanding the role of interleukin-22 in renal disease
Interleukin 22（IL-22），a member of IL-10 cytokine superfamily，is dominantly produced by innate lymphoid cells and CD4+ T helper subtypes such as Th17 and Th22 cells.And interleukin-22 receptor （IL-22R） is a dimer composed of IL-22R1 and IL-10R2 subunit.IL-22 plays a role by conjugating with IL-22R.Re...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.01.011 |
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| Summary: | Interleukin 22（IL-22），a member of IL-10 cytokine superfamily，is dominantly produced by innate lymphoid cells and CD4+ T helper subtypes such as Th17 and Th22 cells.And interleukin-22 receptor （IL-22R） is a dimer composed of IL-22R1 and IL-10R2 subunit.IL-22 plays a role by conjugating with IL-22R.Recently IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity.However，IL-22 may play a protective or pathogenic role in the occurrence and development of inflammatory and autoimmune diseases.This review summarized the latest researches of IL-22 in renal injury-related diseases. |
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| ISSN: | 1671-2390 |