Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial.

Optimal protamine dosing after cardiopulmonary bypass: The PRODOSE adaptive randomised controlled trial.

<h4>Background</h4>The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the dose of heparin required pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models of heparin clearance is postulated to improve protamine dosing precision a...

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Bibliographic Details
Main Authors: Lachlan F Miles, Christiana Burt, Joseph Arrowsmith, Mikel A McKie, Sofia S Villar, Pooveshnie Govender, Ruth Shaylor, Zihui Tan, Ravi De Silva, Florian Falter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-06-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003658&type=printable
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