Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications
The prevalent oral diseases, such as dental caries, chronic gingivitis, and periodontitis, which are primarily caused by pathogenic bacteria, pose significant public health risks and impose substantial economic burdens. However, conventional treatment strategies for oral pathogens rely on mechanical...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Advanced Sensor and Energy Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773045X25000081 |
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| author | Ke Quan Yuqing Zeng Sijia Gao Yanli Lei Le Yang Yibo Zhou Lucky Poh Wah Goh Zhihe Qing |
| author_facet | Ke Quan Yuqing Zeng Sijia Gao Yanli Lei Le Yang Yibo Zhou Lucky Poh Wah Goh Zhihe Qing |
| author_sort | Ke Quan |
| collection | DOAJ |
| description | The prevalent oral diseases, such as dental caries, chronic gingivitis, and periodontitis, which are primarily caused by pathogenic bacteria, pose significant public health risks and impose substantial economic burdens. However, conventional treatment strategies for oral pathogens rely on mechanical debridement and antibiotic treatment, which remain unsatisfactory and contribute to the emergence of antimicrobial resistance pathogens. The escalating crisis of antibiotic resistance and the intricate microbial communities in oral niches urgently demand innovative antimicrobial strategies that can overcome these issues. Metal-bearing nanomaterials (MBNs), as an integration of metallic components with other substances such as polymers or inorganic materials, have demonstrated improved antimicrobial effectiveness while mitigating the toxicity associated with pure metals in oral environments. This review provides an innovative overview of designing and utilizing MBNs for oral antimicrobial applications, bridging the gap between nanomaterial design and clinical dentistry needs while guiding the development of next-generation antimicrobials in the post-antibiotic era. Firstly, we categorize and elucidate the main antibacterial mechanisms of metallic components in MBNs. Furthermore, a comprehensive summary is provided on the up-to-date advancements in using MBNs for oral antibacterial purposes, highlighting the pivotal role of metals in enhancing antibacterial properties. Finally, we discuss the existing challenges and potential future developments to establish a theoretical foundation for ongoing progress and clinical approval. |
| format | Article |
| id | doaj-art-c7ebf893d4044f8fa068f9ee83d413e7 |
| institution | Kabale University |
| issn | 2773-045X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advanced Sensor and Energy Materials |
| spelling | doaj-art-c7ebf893d4044f8fa068f9ee83d413e72025-08-20T03:47:33ZengElsevierAdvanced Sensor and Energy Materials2773-045X2025-06-014210014110.1016/j.asems.2025.100141Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applicationsKe Quan0Yuqing Zeng1Sijia Gao2Yanli Lei3Le Yang4Yibo Zhou5Lucky Poh Wah Goh6Zhihe Qing7Hunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, ChinaHunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, ChinaHunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, ChinaHunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, ChinaHunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China; Corresponding author.Hunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, ChinaFaculty of Science and Natural Resources, University Malaysia Sabah, 88400 Kota Kinabalu, Sabah, MalaysiaHunan Provincial Key Laboratory of Cytochemistry, School of Food and Bioengineering, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China; Corresponding author.The prevalent oral diseases, such as dental caries, chronic gingivitis, and periodontitis, which are primarily caused by pathogenic bacteria, pose significant public health risks and impose substantial economic burdens. However, conventional treatment strategies for oral pathogens rely on mechanical debridement and antibiotic treatment, which remain unsatisfactory and contribute to the emergence of antimicrobial resistance pathogens. The escalating crisis of antibiotic resistance and the intricate microbial communities in oral niches urgently demand innovative antimicrobial strategies that can overcome these issues. Metal-bearing nanomaterials (MBNs), as an integration of metallic components with other substances such as polymers or inorganic materials, have demonstrated improved antimicrobial effectiveness while mitigating the toxicity associated with pure metals in oral environments. This review provides an innovative overview of designing and utilizing MBNs for oral antimicrobial applications, bridging the gap between nanomaterial design and clinical dentistry needs while guiding the development of next-generation antimicrobials in the post-antibiotic era. Firstly, we categorize and elucidate the main antibacterial mechanisms of metallic components in MBNs. Furthermore, a comprehensive summary is provided on the up-to-date advancements in using MBNs for oral antibacterial purposes, highlighting the pivotal role of metals in enhancing antibacterial properties. Finally, we discuss the existing challenges and potential future developments to establish a theoretical foundation for ongoing progress and clinical approval.http://www.sciencedirect.com/science/article/pii/S2773045X25000081MetalNanomaterialsNanozymesOral antimicrobial |
| spellingShingle | Ke Quan Yuqing Zeng Sijia Gao Yanli Lei Le Yang Yibo Zhou Lucky Poh Wah Goh Zhihe Qing Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications Advanced Sensor and Energy Materials Metal Nanomaterials Nanozymes Oral antimicrobial |
| title | Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications |
| title_full | Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications |
| title_fullStr | Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications |
| title_full_unstemmed | Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications |
| title_short | Metal-bearing nanomaterials for oral antibacteria: Mechanisms and applications |
| title_sort | metal bearing nanomaterials for oral antibacteria mechanisms and applications |
| topic | Metal Nanomaterials Nanozymes Oral antimicrobial |
| url | http://www.sciencedirect.com/science/article/pii/S2773045X25000081 |
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