Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition
In this study, Drimartol B, a sesquiterpene coumarin isolated from the edible powder of Artemisia sphaerocephala seeds, was investigated for its potential anti-NSCLC effects. Our findings showed that drimartol B inhibited the proliferation of both A549 and NCI-H1975 cells. Mechanistic studies reveal...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006492 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841545537272152064 |
|---|---|
| author | Jiwen Li Zhongyu Li Mengru Cui Mei Sun Lei Men Xiaojie Gong Keke Li |
| author_facet | Jiwen Li Zhongyu Li Mengru Cui Mei Sun Lei Men Xiaojie Gong Keke Li |
| author_sort | Jiwen Li |
| collection | DOAJ |
| description | In this study, Drimartol B, a sesquiterpene coumarin isolated from the edible powder of Artemisia sphaerocephala seeds, was investigated for its potential anti-NSCLC effects. Our findings showed that drimartol B inhibited the proliferation of both A549 and NCI-H1975 cells. Mechanistic studies revealed that Drimartol B induced cell cycle arrest, decreased mitochondrial membrane potential, reduced Bcl-2, and increased Bax, Caspase-9, and -3 levels, thereby promoting apoptosis. Additionally, network pharmacology identified the PI3K/AKT/FoxO3a pathway as a key target. Molecular docking demonstrated favorable binding affinities between drimartol B and these proteins. Moreover, the regulatory role of drimartol B in NSCLC cells via PI3K/AKT/FoxO3a pathway was confirmed by co-treatment with SC-79 or JY-2. Overall, our findings reveal that drimartol B exerts anticancer effects on NSCLC cells via modulation of the PI3K/AKT/FoxO3a pathway. The future perspective of drimartol B as a dietary component for NSCLC treatment suggests its possible utility in personalized nutrition approaches. |
| format | Article |
| id | doaj-art-c7ead230771548bdbce395145bedc721 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c7ead230771548bdbce395145bedc7212025-01-12T05:24:46ZengElsevierJournal of Functional Foods1756-46462025-01-01124106646Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibitionJiwen Li0Zhongyu Li1Mengru Cui2Mei Sun3Lei Men4Xiaojie Gong5Keke Li6School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, PR ChinaKey Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, PR ChinaKey Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, PR ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, PR ChinaKey Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, PR ChinaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116034, PR China; Key Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, PR China; Corresponding authors at: College of Life Science, Dalian Minzu University, No.18 Liaohe West Road, Dalian Economic and Technological Development Zone, Dalian 116600, PR China.Key Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, PR China; Corresponding authors at: College of Life Science, Dalian Minzu University, No.18 Liaohe West Road, Dalian Economic and Technological Development Zone, Dalian 116600, PR China.In this study, Drimartol B, a sesquiterpene coumarin isolated from the edible powder of Artemisia sphaerocephala seeds, was investigated for its potential anti-NSCLC effects. Our findings showed that drimartol B inhibited the proliferation of both A549 and NCI-H1975 cells. Mechanistic studies revealed that Drimartol B induced cell cycle arrest, decreased mitochondrial membrane potential, reduced Bcl-2, and increased Bax, Caspase-9, and -3 levels, thereby promoting apoptosis. Additionally, network pharmacology identified the PI3K/AKT/FoxO3a pathway as a key target. Molecular docking demonstrated favorable binding affinities between drimartol B and these proteins. Moreover, the regulatory role of drimartol B in NSCLC cells via PI3K/AKT/FoxO3a pathway was confirmed by co-treatment with SC-79 or JY-2. Overall, our findings reveal that drimartol B exerts anticancer effects on NSCLC cells via modulation of the PI3K/AKT/FoxO3a pathway. The future perspective of drimartol B as a dietary component for NSCLC treatment suggests its possible utility in personalized nutrition approaches.http://www.sciencedirect.com/science/article/pii/S1756464624006492Drimartol BNon-small cell lung cancerApoptosisNetwork pharmacologyMolecular dockingPI3K/AKT/FoxO3a |
| spellingShingle | Jiwen Li Zhongyu Li Mengru Cui Mei Sun Lei Men Xiaojie Gong Keke Li Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition Journal of Functional Foods Drimartol B Non-small cell lung cancer Apoptosis Network pharmacology Molecular docking PI3K/AKT/FoxO3a |
| title | Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition |
| title_full | Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition |
| title_fullStr | Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition |
| title_full_unstemmed | Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition |
| title_short | Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition |
| title_sort | drimartol b a sesquiterpene coumarin of the edible powder of artemisia sphaerocephala seed induced apoptosis in nsclc cells via pi3k akt foxo3a pathway inhibition |
| topic | Drimartol B Non-small cell lung cancer Apoptosis Network pharmacology Molecular docking PI3K/AKT/FoxO3a |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006492 |
| work_keys_str_mv | AT jiwenli drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT zhongyuli drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT mengrucui drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT meisun drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT leimen drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT xiaojiegong drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition AT kekeli drimartolbasesquiterpenecoumarinoftheediblepowderofartemisiasphaerocephalaseedinducedapoptosisinnsclccellsviapi3kaktfoxo3apathwayinhibition |