Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction

Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction

Recent bioassay studies have unexpectedly supported the high (computationally predicted) binding affinities of angiotensin receptor blockers (ARBs) at α-adrenergic receptors (αARs) in isolated smooth muscle. Computational predictions from ligand docking studies are consistent with very low concentra...

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Bibliographic Details
Main Authors: Harry Ridgway, Graham J. Moore, Laura Kate Gadanec, John M. Matsoukas
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
alpha-adrenergic receptor
angiotensin II type 1 receptor
angiotensin receptor blockers
bisartans
computer-aided docking simulations
G-protein-coupled receptors
Online Access:https://www.mdpi.com/2218-273X/15/6/855
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