Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches
Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Little progress has been in the treatment of this condition since its introduction some 30 years ago. It's accepted that HFpEF is heterogeneous in many ways, ethologically an...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2021-07-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2512 |
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| author | A. A. Shchendrygina K. A. Zhbanov E. V. Privalova A. O. Yusupova Yu. A. Danilogorskaya E. Yu. Salakheeva I. Ya. Sokolova S. A. Tsatsurova A. A. Ageeva Yu. N. Belenkov |
| author_facet | A. A. Shchendrygina K. A. Zhbanov E. V. Privalova A. O. Yusupova Yu. A. Danilogorskaya E. Yu. Salakheeva I. Ya. Sokolova S. A. Tsatsurova A. A. Ageeva Yu. N. Belenkov |
| author_sort | A. A. Shchendrygina |
| collection | DOAJ |
| description | Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Little progress has been in the treatment of this condition since its introduction some 30 years ago. It's accepted that HFpEF is heterogeneous in many ways, ethologically and phenotypically. The underlying mechanisms of the syndrome are not clear. Recently, it has been shown that the diagnostic criteria for HFpEF lacks sensitivity and specificity. Novel treatment approaches, which were developed based on current HFpEF pathophysiological concepts, did not show either clinical or prognostic benefit for patients. Therefore, there is an urgent need to revise current diagnostic approaches and to further investigate the underlying mechanisms. Recently, two novel diagnostic score systems were proposed: H2PEF and HFA-PEFF. Recently, a number of phase II and III randomized control trials have been completed. Here, the authors discuss the potential novel diagnostic approaches to HFpEF and treatment perspectives. |
| format | Article |
| id | doaj-art-c7ce94c4d13c4fb0b9597a86d8501960 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-c7ce94c4d13c4fb0b9597a86d85019602025-08-23T10:00:34ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532021-07-0117347648310.20996/1819-6446-2021-05-011917Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic ApproachesA. A. Shchendrygina0K. A. Zhbanov1E. V. Privalova2A. O. Yusupova3Yu. A. Danilogorskaya4E. Yu. Salakheeva5I. Ya. Sokolova6S. A. Tsatsurova7A. A. Ageeva8Yu. N. Belenkov9I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Heart failure with preserved ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Little progress has been in the treatment of this condition since its introduction some 30 years ago. It's accepted that HFpEF is heterogeneous in many ways, ethologically and phenotypically. The underlying mechanisms of the syndrome are not clear. Recently, it has been shown that the diagnostic criteria for HFpEF lacks sensitivity and specificity. Novel treatment approaches, which were developed based on current HFpEF pathophysiological concepts, did not show either clinical or prognostic benefit for patients. Therefore, there is an urgent need to revise current diagnostic approaches and to further investigate the underlying mechanisms. Recently, two novel diagnostic score systems were proposed: H2PEF and HFA-PEFF. Recently, a number of phase II and III randomized control trials have been completed. Here, the authors discuss the potential novel diagnostic approaches to HFpEF and treatment perspectives.https://www.rpcardio.online/jour/article/view/2512chronic heart failureheart failure with intact ejection fractionchfhfpef |
| spellingShingle | A. A. Shchendrygina K. A. Zhbanov E. V. Privalova A. O. Yusupova Yu. A. Danilogorskaya E. Yu. Salakheeva I. Ya. Sokolova S. A. Tsatsurova A. A. Ageeva Yu. N. Belenkov Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches Рациональная фармакотерапия в кардиологии chronic heart failure heart failure with intact ejection fraction chf hfpef |
| title | Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches |
| title_full | Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches |
| title_fullStr | Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches |
| title_full_unstemmed | Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches |
| title_short | Heart Failure with Perserved Ejection Fraction Current Diagnostic and Therapeutic Approaches |
| title_sort | heart failure with perserved ejection fraction current diagnostic and therapeutic approaches |
| topic | chronic heart failure heart failure with intact ejection fraction chf hfpef |
| url | https://www.rpcardio.online/jour/article/view/2512 |
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