Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases
The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cyt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510628/full |
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| author | Hui Zhi Hui Fu Yunxin Zhang Ni Fan Chengcheng Zhao Yunfei Li Yujiao Sun Yingpeng Li |
| author_facet | Hui Zhi Hui Fu Yunxin Zhang Ni Fan Chengcheng Zhao Yunfei Li Yujiao Sun Yingpeng Li |
| author_sort | Hui Zhi |
| collection | DOAJ |
| description | The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer. Traditional Chinese Medicines (TCMs), which have a long history of use, have been associated with positive effects in disease prevention and treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) and active compounds (e.g., Glabridin, Ginsenoside Rd) can modulate the cGAS-STING signaling pathway, thereby influencing the progression of inflammatory, infectious, or oncological diseases. This review explores the mechanisms by which TCMs interact with the cGAS-STING pathway to regulate immunity, focusing on their roles in infectious diseases, malignancies, and autoimmune disorders. |
| format | Article |
| id | doaj-art-c7cae8e8df0e4bb6876110b5dfb71e4e |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c7cae8e8df0e4bb6876110b5dfb71e4e2024-12-16T06:18:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15106281510628Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseasesHui Zhi0Hui Fu1Yunxin Zhang2Ni Fan3Chengcheng Zhao4Yunfei Li5Yujiao Sun6Yingpeng Li7College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaExperimental Teaching and Practical Training Center, Heilongjiang University of Chinese Medicine, Harbin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaThe cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer. Traditional Chinese Medicines (TCMs), which have a long history of use, have been associated with positive effects in disease prevention and treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) and active compounds (e.g., Glabridin, Ginsenoside Rd) can modulate the cGAS-STING signaling pathway, thereby influencing the progression of inflammatory, infectious, or oncological diseases. This review explores the mechanisms by which TCMs interact with the cGAS-STING pathway to regulate immunity, focusing on their roles in infectious diseases, malignancies, and autoimmune disorders.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510628/fullcGAS-STING pathwaytraditional Chinese medicineimmunitydiseasecancerinfection6 cGAS-STING pathway |
| spellingShingle | Hui Zhi Hui Fu Yunxin Zhang Ni Fan Chengcheng Zhao Yunfei Li Yujiao Sun Yingpeng Li Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases Frontiers in Immunology cGAS-STING pathway traditional Chinese medicine immunity disease cancer infection6 cGAS-STING pathway |
| title | Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases |
| title_full | Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases |
| title_fullStr | Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases |
| title_full_unstemmed | Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases |
| title_short | Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases |
| title_sort | progress of cgas sting signaling pathway based modulation of immune response by traditional chinese medicine in clinical diseases |
| topic | cGAS-STING pathway traditional Chinese medicine immunity disease cancer infection6 cGAS-STING pathway |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510628/full |
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