Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018
BackgroundThe oxidative balance score (OBS) is a comprehensive concept that includes 16 dietary components and four lifestyle factors to assess an individual's exposure to pro-oxidants and antioxidants. This study aims to explore the relationship between OBS and the risk of chronic kidney disea...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1406780/full |
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| author | Cong Liu Jiju Yang Hongdian Li Yuanyuan Deng Pengfei He Jiao Zhang Mianzhi Zhang Mianzhi Zhang Mianzhi Zhang |
| author_facet | Cong Liu Jiju Yang Hongdian Li Yuanyuan Deng Pengfei He Jiao Zhang Mianzhi Zhang Mianzhi Zhang Mianzhi Zhang |
| author_sort | Cong Liu |
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| description | BackgroundThe oxidative balance score (OBS) is a comprehensive concept that includes 16 dietary components and four lifestyle factors to assess an individual's exposure to pro-oxidants and antioxidants. This study aims to explore the relationship between OBS and the risk of chronic kidney disease (CKD).MethodsThis cross-sectional study included nationally representative National Health and Nutrition Examination Survey (NHANES) participants aged 18 and above from 2005 to 2018. The OBS, a novel concept derived from multiple dietary (pro-oxidant and antioxidant nutrients) and lifestyle exposures (including smoking, alcohol consumption, obesity, and physical activity), serves as a useful tool for assessing an individual's oxidative stress status. The continuous variable OBS was converted into categorical variables by quartiles. Covariates included age, gender, race, education level, marital status, poverty-income ratio, sleep duration, depression, hypertension, diabetes, hyperlipidemia, cardiovascular disease, use of hypoglycemic medications, and use of antihypertensive medications. The relationship between OBS and CKD was explored using multiple logistic regression analysis and restricted cubic spline models. Additionally, subgroup analyses, interaction tests, and sensitivity analyses were conducted to validate the stability of the results.ResultsA total of 25,118 NHANES participants were included in this study. The weighted prevalence of CKD was 14.97%. In the fully adjusted model, compared to the lowest OBS quartile, participants in the highest quartile had a 26% reduced risk of CKD (OR = 0.74, 95%CI: 0.63–0.87, p < 0.001). In restricted cubic spline regression, there was a linear association between OBS and CKD. The results of subgroup analysis and sensitivity analysis remain consistent. A significant interaction was found in the stratified analysis by age group (p for interaction = 0.012), suggesting that individuals older than 60 years may benefit more significantly from an increase in OBS scores compared to those aged 60 years or younger.ConclusionThis study demonstrates that higher OBS is associated with a lower risk of CKD, particularly among the elderly population, providing innovative insights and preliminary evidence for the development of preventive strategies against CKD. |
| format | Article |
| id | doaj-art-c7bd93df828747a0ba8644aeac017463 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-c7bd93df828747a0ba8644aeac0174632025-01-03T05:10:23ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14067801406780Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018Cong Liu0Jiju Yang1Hongdian Li2Yuanyuan Deng3Pengfei He4Jiao Zhang5Mianzhi Zhang6Mianzhi Zhang7Mianzhi Zhang8Department of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaDepartment of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaTianjin Famous Chinese Medicine Inheritance Workshop of Mianzhi Zhang, Tianjin, ChinaBackgroundThe oxidative balance score (OBS) is a comprehensive concept that includes 16 dietary components and four lifestyle factors to assess an individual's exposure to pro-oxidants and antioxidants. This study aims to explore the relationship between OBS and the risk of chronic kidney disease (CKD).MethodsThis cross-sectional study included nationally representative National Health and Nutrition Examination Survey (NHANES) participants aged 18 and above from 2005 to 2018. The OBS, a novel concept derived from multiple dietary (pro-oxidant and antioxidant nutrients) and lifestyle exposures (including smoking, alcohol consumption, obesity, and physical activity), serves as a useful tool for assessing an individual's oxidative stress status. The continuous variable OBS was converted into categorical variables by quartiles. Covariates included age, gender, race, education level, marital status, poverty-income ratio, sleep duration, depression, hypertension, diabetes, hyperlipidemia, cardiovascular disease, use of hypoglycemic medications, and use of antihypertensive medications. The relationship between OBS and CKD was explored using multiple logistic regression analysis and restricted cubic spline models. Additionally, subgroup analyses, interaction tests, and sensitivity analyses were conducted to validate the stability of the results.ResultsA total of 25,118 NHANES participants were included in this study. The weighted prevalence of CKD was 14.97%. In the fully adjusted model, compared to the lowest OBS quartile, participants in the highest quartile had a 26% reduced risk of CKD (OR = 0.74, 95%CI: 0.63–0.87, p < 0.001). In restricted cubic spline regression, there was a linear association between OBS and CKD. The results of subgroup analysis and sensitivity analysis remain consistent. A significant interaction was found in the stratified analysis by age group (p for interaction = 0.012), suggesting that individuals older than 60 years may benefit more significantly from an increase in OBS scores compared to those aged 60 years or younger.ConclusionThis study demonstrates that higher OBS is associated with a lower risk of CKD, particularly among the elderly population, providing innovative insights and preliminary evidence for the development of preventive strategies against CKD.https://www.frontiersin.org/articles/10.3389/fnut.2024.1406780/fullchronic kidney diseaseoxidative balance scoreNHANESa cross-sectional studydietary components |
| spellingShingle | Cong Liu Jiju Yang Hongdian Li Yuanyuan Deng Pengfei He Jiao Zhang Mianzhi Zhang Mianzhi Zhang Mianzhi Zhang Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 Frontiers in Nutrition chronic kidney disease oxidative balance score NHANES a cross-sectional study dietary components |
| title | Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 |
| title_full | Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 |
| title_fullStr | Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 |
| title_full_unstemmed | Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 |
| title_short | Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 |
| title_sort | association between chronic kidney disease and oxidative balance score national health and nutrition examination survey nhanes 2005 2018 |
| topic | chronic kidney disease oxidative balance score NHANES a cross-sectional study dietary components |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1406780/full |
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