Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload

Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload

Abstract Background Follicle development is a complicated biological process that produces mature oocytes, and requires nutrients, growth factors, and steroids produced by ovarian granulosa cells (GCs). High fork head box J2 (FOXJ2) expression might negatively regulate ovarian function; however, the...

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Bibliographic Details
Main Authors: Yunxia Zhang, Qiqian Wu, Furong Bai, Yanqin Hu, Bufang Xu, Yujie Tang, Jingwen Wu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Ovarian Research
Subjects:
Follicle development
Granulosa cells
Apoptosis
Mitochondrial calcium overload
FOXJ2
MCU
Online Access:https://doi.org/10.1186/s13048-025-01651-0
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