Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies

Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies

Urease enzyme inhibition is a well-established and promising strategy for preventing the harmful effects of ureolytic bacterial infections, particularly those caused by H. pylori. However, acetohydroxamic acid, the only approved urease inhibitor, has limited use due to significant side effects, incl...

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Bibliographic Details
Main Authors: Hassan Sepehrmansourie, Mohammad Azimi, Ahmad Ebadi, Gholamabbas Chehardoli, Mohammad Ali Zolfigol, Massoud Amanlou, Mohammad Nazari Montazer, Mohammad Mahdavi, Zahra Najafi
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Coumarin
Acetohydrazide
1,2,3-Triazole
Urease inhibition
Molecular docking
Molecular dynamics simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024173525
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