Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle>
Purpose This study aimed to investigate the efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for the treatment of synovial hyperplasia in the knee joints of antigen-induced arthritis (AIA) model rabbits.Methods Forty Japanese large-eared white rabbits were divided...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2328113 |
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| author | Qi Xu Xiao-hui Xu Ze-zheng Liu Jian-bi Zhu Huan-huan Ding Chun-chun Jin Zhi-han Yan |
| author_facet | Qi Xu Xiao-hui Xu Ze-zheng Liu Jian-bi Zhu Huan-huan Ding Chun-chun Jin Zhi-han Yan |
| author_sort | Qi Xu |
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| description | Purpose This study aimed to investigate the efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for the treatment of synovial hyperplasia in the knee joints of antigen-induced arthritis (AIA) model rabbits.Methods Forty Japanese large-eared white rabbits were divided into AIA and control groups. After successful induction of the AIA model, the knee joints were randomly assigned to RFA and non-RFA groups. The RFA group underwent ultrasound-guided RFA to treat synovial hyperplasia in the knee joint. Dynamic observation of various detection indices was conducted to evaluate the safety and effectiveness of the RFA procedure.Results Successful synovial ablation was achieved in the RFA group, with no intraoperative or perioperative mortality. Postoperative the circumference of the knee joint reached a peak before decreasing in the third week after surgery. The incidence and diameter of postoperative skin ulcers were not significantly different compared to the non-RFA group (p > .05). Anatomical examination revealed an intact intermuscular fascia around the ablated area in the RFA group. The ablated synovial tissue initially presented as a white mass, which subsequently liquefied into a milky white viscous fluid. Gross articular cartilage was observed, along with liquefied necrosis of the synovium on pathological histology and infiltration of inflammatory cells in the surrounding soft tissue.Conclusion The experimental results demonstrated that ultrasound-guided RFA of the knee in the treatment of synovial hyperplasia in AIA model animals was both effective and safe. |
| format | Article |
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| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-c7b5bada56234b2c85ee935d29e8d9be2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2328113Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle>Qi Xu0Xiao-hui Xu1Ze-zheng Liu2Jian-bi Zhu3Huan-huan Ding4Chun-chun Jin5Zhi-han Yan6Department of Ultrasound, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Medical and Health Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Ultrasound, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Ultrasound, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Ultrasound, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Ultrasound, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, ChinaPurpose This study aimed to investigate the efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for the treatment of synovial hyperplasia in the knee joints of antigen-induced arthritis (AIA) model rabbits.Methods Forty Japanese large-eared white rabbits were divided into AIA and control groups. After successful induction of the AIA model, the knee joints were randomly assigned to RFA and non-RFA groups. The RFA group underwent ultrasound-guided RFA to treat synovial hyperplasia in the knee joint. Dynamic observation of various detection indices was conducted to evaluate the safety and effectiveness of the RFA procedure.Results Successful synovial ablation was achieved in the RFA group, with no intraoperative or perioperative mortality. Postoperative the circumference of the knee joint reached a peak before decreasing in the third week after surgery. The incidence and diameter of postoperative skin ulcers were not significantly different compared to the non-RFA group (p > .05). Anatomical examination revealed an intact intermuscular fascia around the ablated area in the RFA group. The ablated synovial tissue initially presented as a white mass, which subsequently liquefied into a milky white viscous fluid. Gross articular cartilage was observed, along with liquefied necrosis of the synovium on pathological histology and infiltration of inflammatory cells in the surrounding soft tissue.Conclusion The experimental results demonstrated that ultrasound-guided RFA of the knee in the treatment of synovial hyperplasia in AIA model animals was both effective and safe.https://www.tandfonline.com/doi/10.1080/02656736.2024.2328113Percutaneous radiofrequency ablationsynovial hyperplasiaanimal experiment researchultrasonographyarthritis treatment |
| spellingShingle | Qi Xu Xiao-hui Xu Ze-zheng Liu Jian-bi Zhu Huan-huan Ding Chun-chun Jin Zhi-han Yan Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> International Journal of Hyperthermia Percutaneous radiofrequency ablation synovial hyperplasia animal experiment research ultrasonography arthritis treatment |
| title | Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> |
| title_full | Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> |
| title_fullStr | Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> |
| title_full_unstemmed | Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> |
| title_short | Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia<subtitle>An animal experimental study</subtitle> |
| title_sort | efficacy and safety of ultrasound guided percutaneous radiofrequency ablation for synovial hyperplasia subtitle an animal experimental study subtitle |
| topic | Percutaneous radiofrequency ablation synovial hyperplasia animal experiment research ultrasonography arthritis treatment |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2328113 |
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