Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection
Abstract Healthcare Workers (HCWs) are at ongoing risk of SARS-CoV-2 infection, potentially contributing to its transmission. This study assessed full vaccination and vaccination timeliness impact on SARS-CoV-2 infections among HCWs in Italy’s Marche Region, using Healthcare Utilization Databases. W...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84100-0 |
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| author | Edlira Skrami Andrea Faragalli Marica Iommi Marco Morbidoni Cristina Mancini Antonella Guidi Annalisa Cardone Marco Pompili Pietro Serafini Remo Appignanesi Luigi Ferrante Flavia Carle |
| author_facet | Edlira Skrami Andrea Faragalli Marica Iommi Marco Morbidoni Cristina Mancini Antonella Guidi Annalisa Cardone Marco Pompili Pietro Serafini Remo Appignanesi Luigi Ferrante Flavia Carle |
| author_sort | Edlira Skrami |
| collection | DOAJ |
| description | Abstract Healthcare Workers (HCWs) are at ongoing risk of SARS-CoV-2 infection, potentially contributing to its transmission. This study assessed full vaccination and vaccination timeliness impact on SARS-CoV-2 infections among HCWs in Italy’s Marche Region, using Healthcare Utilization Databases. We evaluated vaccination coverage and its associated factors. The cohort comprised 21,118 HCWs aged 18–70 from the region’s five Local Health Authorities (LHA), enrolled between February 2020 - May 2021. Factors associated with full vaccination were assessed using multiple logistic regression. The impact of vaccination status, time to vaccination, occupational role, age, gender, and health status on infection risk was analysed with a multiple Cox regression model, adjusting for vaccination coverage velocity, swabbing probability, and monthly intensive care unit admissions rate in each LHA. Of the cohort, 81.2% were fully vaccinated. Factors associated with full vaccination included age, role, LHA, prior infection, and health status. Vaccination reduced infection risk by 77% (95% CI: 70–82). Infection risk was higher among healthcare assistants, nurses/physiotherapists/technicians compared to physicians, among male HCWs, and it decreased as vaccination timeliness increased. Vaccination timeliness is crucial for reducing SARS-CoV-2 infection risk among HCWs, regardless of their characteristics. This underscores the importance of efficiently organizing vaccination administration across different territories and for all HCW categories. |
| format | Article |
| id | doaj-art-c7b4c5b555424963a5197bd1cc496fcb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c7b4c5b555424963a5197bd1cc496fcb2025-01-05T12:14:41ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84100-0Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infectionEdlira Skrami0Andrea Faragalli1Marica Iommi2Marco Morbidoni3Cristina Mancini4Antonella Guidi5Annalisa Cardone6Marco Pompili7Pietro Serafini8Remo Appignanesi9Luigi Ferrante10Flavia Carle11Center of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Università Politecnica delle MarcheCenter of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Università Politecnica delle MarcheCenter of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Università Politecnica delle MarcheEnvironment, Health and Epidemiology Department, Hygiene and Public Health Service, Local Health Authority AnconaEnvironment, Health and Epidemiology Department, Hygiene and Public Health Service, Local Health Authority AnconaEnvironment, Health and Epidemiology Department, Hygiene and Public Health Service, Local Health Authority AnconaEnvironment, Health and Epidemiology Department, Hygiene and Public Health Service, Local Health Authority AnconaRegional Health Agency of MarcheControl Management Department, Local Health Authority AnconaRisk Management and Clinical Governance Unit, Local Health Authority Ascoli PicenoCenter of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Università Politecnica delle MarcheCenter of Epidemiology, Biostatistics and Medical Information Technology, Department of Biomedical Sciences and Public Health, Università Politecnica delle MarcheAbstract Healthcare Workers (HCWs) are at ongoing risk of SARS-CoV-2 infection, potentially contributing to its transmission. This study assessed full vaccination and vaccination timeliness impact on SARS-CoV-2 infections among HCWs in Italy’s Marche Region, using Healthcare Utilization Databases. We evaluated vaccination coverage and its associated factors. The cohort comprised 21,118 HCWs aged 18–70 from the region’s five Local Health Authorities (LHA), enrolled between February 2020 - May 2021. Factors associated with full vaccination were assessed using multiple logistic regression. The impact of vaccination status, time to vaccination, occupational role, age, gender, and health status on infection risk was analysed with a multiple Cox regression model, adjusting for vaccination coverage velocity, swabbing probability, and monthly intensive care unit admissions rate in each LHA. Of the cohort, 81.2% were fully vaccinated. Factors associated with full vaccination included age, role, LHA, prior infection, and health status. Vaccination reduced infection risk by 77% (95% CI: 70–82). Infection risk was higher among healthcare assistants, nurses/physiotherapists/technicians compared to physicians, among male HCWs, and it decreased as vaccination timeliness increased. Vaccination timeliness is crucial for reducing SARS-CoV-2 infection risk among HCWs, regardless of their characteristics. This underscores the importance of efficiently organizing vaccination administration across different territories and for all HCW categories.https://doi.org/10.1038/s41598-024-84100-0COVID-19SARS-CoV-2Vaccine impactVaccine timelinessHealthcare workersHealthcare Utilisation databases |
| spellingShingle | Edlira Skrami Andrea Faragalli Marica Iommi Marco Morbidoni Cristina Mancini Antonella Guidi Annalisa Cardone Marco Pompili Pietro Serafini Remo Appignanesi Luigi Ferrante Flavia Carle Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection Scientific Reports COVID-19 SARS-CoV-2 Vaccine impact Vaccine timeliness Healthcare workers Healthcare Utilisation databases |
| title | Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection |
| title_full | Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection |
| title_fullStr | Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection |
| title_full_unstemmed | Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection |
| title_short | Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection |
| title_sort | healthcare workers safety a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against sars cov 2 infection |
| topic | COVID-19 SARS-CoV-2 Vaccine impact Vaccine timeliness Healthcare workers Healthcare Utilisation databases |
| url | https://doi.org/10.1038/s41598-024-84100-0 |
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