Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage
Background: Prolonged pretreatment time may be harmful to frozen embryo’s developmental potential. This study was conducted to evaluate the effect of different equilibration times on the clinical and neonatal outcomes of frozen-warmed blastocyst transfer. Methods: This is a retrospective study based...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009197 |
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| author | Liuguang Zhang Romualdo Sciorio Yuhu Li Ning Li |
| author_facet | Liuguang Zhang Romualdo Sciorio Yuhu Li Ning Li |
| author_sort | Liuguang Zhang |
| collection | DOAJ |
| description | Background: Prolonged pretreatment time may be harmful to frozen embryo’s developmental potential. This study was conducted to evaluate the effect of different equilibration times on the clinical and neonatal outcomes of frozen-warmed blastocyst transfer. Methods: This is a retrospective study based on data collected from our medical records from March 2018 to March 2022 and including a total of 763 expanded blastocysts from 538 warming blastocyst cycles. These cycles were divided into two groups according to the equilibration time: (A) 6–7 minutes, and (B) 9–10 minutes. The survival rate, clinical, and neonatal outcomes were investigated. Results: The survival, implantation, and clinical pregnancy rates of vitrified-warmed shrinkage blastocyst were not different between the two groups. Other variables analyzed including live birth, multiple gestation, and neonatal outcomes were similar between the two groups. Conclusions: The results of this study illustrated that vitrification of artificially collapsed blastocysts with a shorter equilibration time (6–7 minutes) and pre-vitrification is able to lead to similar clinical and neonatal outcomes in patients undergoing assisted reproductive technology (ART). |
| format | Article |
| id | doaj-art-c77c12a1b0ec4c5f91ccfba4d7280b7c |
| institution | DOAJ |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-c77c12a1b0ec4c5f91ccfba4d7280b7c2025-08-20T03:05:14ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-09-0150919710.31083/j.ceog5009197S0390-6663(23)02203-0Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial ShrinkageLiuguang Zhang0Romualdo Sciorio1Yuhu Li2Ning Li3Center for Reproductive Medicine, Haikou Mary Hospital, 570203 Haikou, Hainan, ChinaEdinburgh Assisted Conception Programme, Edinburgh Fertility Reproductive Endocrine Center (EFREC), Royal Infirmary of Edinburgh, EH16 4SA Edinburgh, UKCenter for Reproductive Medicine, Haikou Mary Hospital, 570203 Haikou, Hainan, ChinaCenter for Reproductive Medicine, Haikou Mary Hospital, 570203 Haikou, Hainan, ChinaBackground: Prolonged pretreatment time may be harmful to frozen embryo’s developmental potential. This study was conducted to evaluate the effect of different equilibration times on the clinical and neonatal outcomes of frozen-warmed blastocyst transfer. Methods: This is a retrospective study based on data collected from our medical records from March 2018 to March 2022 and including a total of 763 expanded blastocysts from 538 warming blastocyst cycles. These cycles were divided into two groups according to the equilibration time: (A) 6–7 minutes, and (B) 9–10 minutes. The survival rate, clinical, and neonatal outcomes were investigated. Results: The survival, implantation, and clinical pregnancy rates of vitrified-warmed shrinkage blastocyst were not different between the two groups. Other variables analyzed including live birth, multiple gestation, and neonatal outcomes were similar between the two groups. Conclusions: The results of this study illustrated that vitrification of artificially collapsed blastocysts with a shorter equilibration time (6–7 minutes) and pre-vitrification is able to lead to similar clinical and neonatal outcomes in patients undergoing assisted reproductive technology (ART).https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009197blastocyst vitrificationartificial collapseexposure to equilibration solutionpregnancy and implantation ratesspontaneous abortionneonatal outcomes |
| spellingShingle | Liuguang Zhang Romualdo Sciorio Yuhu Li Ning Li Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage Clinical and Experimental Obstetrics & Gynecology blastocyst vitrification artificial collapse exposure to equilibration solution pregnancy and implantation rates spontaneous abortion neonatal outcomes |
| title | Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage |
| title_full | Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage |
| title_fullStr | Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage |
| title_full_unstemmed | Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage |
| title_short | Effect of Shorter Pretreatment Time on Clinical and Neonatal Outcomes in Human Blastocysts Vitrification after Artificial Shrinkage |
| title_sort | effect of shorter pretreatment time on clinical and neonatal outcomes in human blastocysts vitrification after artificial shrinkage |
| topic | blastocyst vitrification artificial collapse exposure to equilibration solution pregnancy and implantation rates spontaneous abortion neonatal outcomes |
| url | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009197 |
| work_keys_str_mv | AT liuguangzhang effectofshorterpretreatmenttimeonclinicalandneonataloutcomesinhumanblastocystsvitrificationafterartificialshrinkage AT romualdosciorio effectofshorterpretreatmenttimeonclinicalandneonataloutcomesinhumanblastocystsvitrificationafterartificialshrinkage AT yuhuli effectofshorterpretreatmenttimeonclinicalandneonataloutcomesinhumanblastocystsvitrificationafterartificialshrinkage AT ningli effectofshorterpretreatmenttimeonclinicalandneonataloutcomesinhumanblastocystsvitrificationafterartificialshrinkage |