Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice
We discovered that the phospholipids present in the internal organs of scallops (Patinopecten yessoensis), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of s...
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Elsevier
2024-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005723 |
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| author | Koki Sugimoto Ayano Kosaka Ryota Hosomi Saki Itonori Munehiro Yoshida Kenji Fukunaga |
| author_facet | Koki Sugimoto Ayano Kosaka Ryota Hosomi Saki Itonori Munehiro Yoshida Kenji Fukunaga |
| author_sort | Koki Sugimoto |
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| description | We discovered that the phospholipids present in the internal organs of scallops (Patinopecten yessoensis), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of scallop CAEP on lipid metabolism by comparing it to sphingomyelin. The study involved feeding four-week-old male KK-Ay mice either a high-fat diet or a high-fat diet supplemented with 0.5 wt% each of CAEP and sphingomyelin for 35 days. We found that CAEP intake lowered the serum triacylglycerol content, partly via a reduction in the mRNA expression levels of fatty acid synthesis-related genes in the liver. Furthermore, the CAEP diet reduced the serum and liver cholesterol contents. This effect was partially mediated by the increase in fecal total sterol excretion. Thus, this study indicates CAEP will be employed as a health-promoting component to lower the body’s triacylglycerol and cholesterol contents. |
| format | Article |
| id | doaj-art-c75b9ca73f8b40ba9b97e0b93fc63deb |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c75b9ca73f8b40ba9b97e0b93fc63deb2024-12-14T06:30:11ZengElsevierJournal of Functional Foods1756-46462024-12-01123106569Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay miceKoki Sugimoto0Ayano Kosaka1Ryota Hosomi2Saki Itonori3Munehiro Yoshida4Kenji Fukunaga5Faculty of Food and Nutritional Sciences, Toyo University, 48-1, Oka, Asaka, Saitama 351-8510, Japan; Corresponding author at: Food and Life Sciences, Food and Nutritional Sciences, Toyo University, 48-1, Oka, Asaka, Saitama 351-8510, Japan.Faculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, JapanFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, JapanFaculty of Liberal Arts and Education, Shiga University, 2-5-1, Hiratsu, Otsu, Shiga 520-0862, JapanFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, JapanFaculty of Chemistry, Materials, and Bioengineering, Kansai University, 3-3-35, Yamate-cho, Suita, Osaka 564-8680, JapanWe discovered that the phospholipids present in the internal organs of scallops (Patinopecten yessoensis), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of scallop CAEP on lipid metabolism by comparing it to sphingomyelin. The study involved feeding four-week-old male KK-Ay mice either a high-fat diet or a high-fat diet supplemented with 0.5 wt% each of CAEP and sphingomyelin for 35 days. We found that CAEP intake lowered the serum triacylglycerol content, partly via a reduction in the mRNA expression levels of fatty acid synthesis-related genes in the liver. Furthermore, the CAEP diet reduced the serum and liver cholesterol contents. This effect was partially mediated by the increase in fecal total sterol excretion. Thus, this study indicates CAEP will be employed as a health-promoting component to lower the body’s triacylglycerol and cholesterol contents.http://www.sciencedirect.com/science/article/pii/S1756464624005723Ceramide 2-aminoethylphosphonateScallop (Patinopecten yessoensis)Lipid metabolismSphingolipidsPhospholipids |
| spellingShingle | Koki Sugimoto Ayano Kosaka Ryota Hosomi Saki Itonori Munehiro Yoshida Kenji Fukunaga Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice Journal of Functional Foods Ceramide 2-aminoethylphosphonate Scallop (Patinopecten yessoensis) Lipid metabolism Sphingolipids Phospholipids |
| title | Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice |
| title_full | Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice |
| title_fullStr | Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice |
| title_full_unstemmed | Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice |
| title_short | Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice |
| title_sort | scallop ceramide 2 aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese type ii diabetic kk ay mice |
| topic | Ceramide 2-aminoethylphosphonate Scallop (Patinopecten yessoensis) Lipid metabolism Sphingolipids Phospholipids |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005723 |
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