Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021
Background High body mass index (BMI) is associated with an increased risk of chronic kidney disease (CKD). However, studies on the CKD burden due to high BMI are limited.Methods This research uses data from the Global Burden of Disease (GBD) study to analyze the epidemiological characteristics of C...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512400 |
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| author | Zehui Rao Kaihong Wang Kun Zhou Yuanyuan Duan Yida Zhang |
| author_facet | Zehui Rao Kaihong Wang Kun Zhou Yuanyuan Duan Yida Zhang |
| author_sort | Zehui Rao |
| collection | DOAJ |
| description | Background High body mass index (BMI) is associated with an increased risk of chronic kidney disease (CKD). However, studies on the CKD burden due to high BMI are limited.Methods This research uses data from the Global Burden of Disease (GBD) study to analyze the epidemiological characteristics of CKD due to high BMI from 1990 to 2021, including mortality rate and disability-adjusted life years (DALYs). Age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) were calculated, with stratified analyses by sex, age, and socio-demographic index (SDI) regions. The estimated annual percentage change (EAPC) assessed the trends over 32 years, and a Bayesian age-period-cohort (BAPC) model predicted the disease burden for the next 15 years.Results In 2021, the ASMR and ASDR for CKD attributable to high BMI globally were estimated at 5.06 [95% uncertainty interval (UI): 2.70–7.51] and 122.08 (95% UI: 66.25–180.18) per 100,000 population, respectively. Significant variations in these metrics were observed across sex, age groups, and regions. Between 1990 and 2021, both ASMR and ASDR exhibited an upward trajectory, with projections indicating a continued rise through to 2040.Conclusions Our findings indicate that the CKD burden due to high BMI is increasing, with notable disparities across sex, age, and geographic regions. Targeted public health interventions, particularly those focusing on males and older adults, are essential to address this growing health challenge. |
| format | Article |
| id | doaj-art-c75b32fb47ae4aa78be30b28111c3f8f |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-c75b32fb47ae4aa78be30b28111c3f8f2025-08-20T03:45:44ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2512400Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021Zehui Rao0Kaihong Wang1Kun Zhou2Yuanyuan Duan3Yida Zhang4Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangxi Open University, Nanchang, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaBackground High body mass index (BMI) is associated with an increased risk of chronic kidney disease (CKD). However, studies on the CKD burden due to high BMI are limited.Methods This research uses data from the Global Burden of Disease (GBD) study to analyze the epidemiological characteristics of CKD due to high BMI from 1990 to 2021, including mortality rate and disability-adjusted life years (DALYs). Age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) were calculated, with stratified analyses by sex, age, and socio-demographic index (SDI) regions. The estimated annual percentage change (EAPC) assessed the trends over 32 years, and a Bayesian age-period-cohort (BAPC) model predicted the disease burden for the next 15 years.Results In 2021, the ASMR and ASDR for CKD attributable to high BMI globally were estimated at 5.06 [95% uncertainty interval (UI): 2.70–7.51] and 122.08 (95% UI: 66.25–180.18) per 100,000 population, respectively. Significant variations in these metrics were observed across sex, age groups, and regions. Between 1990 and 2021, both ASMR and ASDR exhibited an upward trajectory, with projections indicating a continued rise through to 2040.Conclusions Our findings indicate that the CKD burden due to high BMI is increasing, with notable disparities across sex, age, and geographic regions. Targeted public health interventions, particularly those focusing on males and older adults, are essential to address this growing health challenge.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512400Chronic kidney diseasehigh BMIGlobal Burden of Diseasetrends |
| spellingShingle | Zehui Rao Kaihong Wang Kun Zhou Yuanyuan Duan Yida Zhang Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 Renal Failure Chronic kidney disease high BMI Global Burden of Disease trends |
| title | Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 |
| title_full | Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 |
| title_fullStr | Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 |
| title_full_unstemmed | Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 |
| title_short | Global burden and epidemic trends of chronic kidney disease attributable to high body mass index: insights from the Global Burden of Disease Study 2021 |
| title_sort | global burden and epidemic trends of chronic kidney disease attributable to high body mass index insights from the global burden of disease study 2021 |
| topic | Chronic kidney disease high BMI Global Burden of Disease trends |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2512400 |
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